about
RabGEFs are a major determinant for specific Rab membrane targetingStructures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylationDevelopment of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complexAnalysis of the eukaryotic prenylome by isoprenoid affinity taggingQuantitative Analysis of Prenylated RhoA Interaction with Its Chaperone, RhoGDIDevelopment of selective, potent RabGGTase inhibitorsGeneration of an intramolecular three-color fluorescence resonance energy transfer probe by site-specific protein labeling.Flexible and general synthesis of functionalized phosphoisoprenoids for the study of prenylation in vivo and in vitro.Rab GTPase prenylation hierarchy and its potential role in choroideremia diseaseA bioorthogonal small-molecule-switch system for controlling protein function in live cells.Spatiotemporal imaging of small GTPases activity in live cellsThe role of the hypervariable C-terminal domain in Rab GTPases membrane targeting.Chemical synthesis and biological function of lipidated proteins."Molecular Activity Painting": Switch-like, Light-Controlled Perturbations inside Living Cells.Chemically induced dimerization: reversible and spatiotemporal control of protein function in cells.Selective chemical labeling of proteins.Mechanisms of action of Rab proteins, key regulators of intracellular vesicular transport.Dual lipidation of the brain-specific Cdc42 isoform regulates its functional properties.A synthetic supramolecular construct modulating protein assembly in cells.Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins.Locking GTPases covalently in their functional states.Analysis of protein prenylation in vitro and in vivo using functionalized phosphoisoprenoids.Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation.Liquid chromatographic analysis and mass spectrometric identification of farnesylated peptides.Tandem orthogonal chemically induced dimerization.Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids.Displaced pi-pi stacking and hydrogen bonds in 3-bromo-N-(2-hydroxy-1,1-dimethylethyl)benzamide.Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes.Synthesis of a fluorescent analogue of geranylgeranyl pyrophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase.Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34.Lift and cut: Anti-host autophagy mechanism of Legionella pneumophila.Semisynthetic lipidated LC3 protein mediates membrane fusion.One-Pot N2C/C2C/N2N Ligation To Trap Weak Protein-Protein Interactions.Semisynthesis of autophagy protein LC3 conjugates.A rapid and fluorogenic TMP-AcBOPDIPY probe for covalent labeling of proteins in live cells.Tunable and photoswitchable chemically induced dimerization for chemo-optogenetic control of protein and organelle positioning.Discovery of Novel Cinchona-Alkaloid-Inspired Oxazatwistane Autophagy Inhibitors.Direct immobilization of oxyamine-modified proteins from cell lysates.Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I.One-Pot Dual-Labeling of a Protein by Two Chemoselective Reactions
P50
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P50
description
hulumtues
@sq
researcher
@en
ricercatore
@it
scheikundige
@nl
հետազոտող
@hy
name
Yaowen Wu
@ast
Yaowen Wu
@de
Yaowen Wu
@en
Yaowen Wu
@es
Yaowen Wu
@nl
Yaowen Wu
@sl
type
label
Yaowen Wu
@ast
Yaowen Wu
@de
Yaowen Wu
@en
Yaowen Wu
@es
Yaowen Wu
@nl
Yaowen Wu
@sl
prefLabel
Yaowen Wu
@ast
Yaowen Wu
@de
Yaowen Wu
@en
Yaowen Wu
@es
Yaowen Wu
@nl
Yaowen Wu
@sl
P214
P227
P1053
N-9802-2015
P108
P1153
15137345100
P21
P214
P227
1060474239
P31
P3829
P496
0000-0002-2573-8736
P7859
viaf-311447860