Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sorting.
about
Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tailCo-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulationProteomic-based identification of CD4-interacting proteins in human primary macrophagesSignal peptide-binding drug as a selective inhibitor of co-translational protein translocationThe SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes.Regulated movement of CD4 in and out of the immunological synapseDefective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss.Anti-HIV agents targeting the interaction of gp120 with the cellular CD4 receptor.Increased interleukin-27 promotes Th1 differentiation in patients with chronic immune thrombocytopenia.The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors.Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycinTwo elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis.Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1.Differential modulation of surface and intracellular protein expression by T cells after stimulation in the presence of monensin or brefeldin A.T-cell-stimulating protein A elicits immune responses during meningococcal carriage and human disease.The Rous sarcoma virus Env glycoprotein contains a highly conserved motif homologous to tyrosine-based endocytosis signals and displays an unusual internalization phenotypeDifferential subcellular localization of the regulatory T-cell protein LAG-3 and the coreceptor CD4.Similar regulation of cell surface human T-cell leukemia virus type 1 (HTLV-1) surface binding proteins in cells highly and poorly transduced by HTLV-1-pseudotyped virionsRegulation of endosome sorting by a specific PP2A isoform.High level of coreceptor-independent HIV transfer induced by contacts between primary CD4 T cells.Immune regulatory mechanisms influence early pathology in spinal cord injury and in spontaneous autoimmune encephalomyelitis.Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission.High-Throughput HIV-Cell Fusion Assay for Discovery of Virus Entry InhibitorsDynasore disrupts trafficking of herpes simplex virus proteinsMyxoma virus induces extensive CD4 downregulation and dissociation of p56lck in infected rabbit CD4+ T lymphocytes.Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules.Modeling Bone Marrow Progenitor Cell Differentiation and Susceptibility to HIV-1 InfectionCD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells.Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cellsPhorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4.Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways.Protein kinase C and NF-κB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infectionThe human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylationDifferential modulation by delta9-tetrahydrocannabinol (∆9)-THC) of CD40 ligand (CD40L) expression in activated mouse splenic CD4+ T cellsDetermination of intracellular cytokines IFN-gamma and IL-4 in canine T lymphocytes by flow cytometry following whole-blood culture.Characterization of a CD38-like 78-kilodalton soluble protein released from B cell lines derived from patients with X-linked agammaglobulinemia.Cell-to-Cell Spread of Retroviruses.Arf6 and Rab22 mediate T cell conjugate formation by regulating clathrin-independent endosomal membrane trafficking.Differential level in co-down-modulation of CD4 and CXCR4 primed by HIV-1 gp120 in response to phorbol ester, PMA, among HIV-1 isolates.
P2860
Q24310700-DEDE7728-55D0-47DD-9A8C-18267BD21562Q24532862-F484EF93-FA4C-4C4C-AB65-F320F16976BBQ28477747-4D226389-EBDE-4BD2-B1EF-380D7105D89CQ28542401-382A4AD1-94C6-4E15-83C3-F8ED78EB854CQ30176171-9753DF24-6078-4D61-BC2D-14732D05F740Q30494182-E0AC8A70-E893-4D91-9C19-03C2C5BD68D5Q30583336-BD779914-DC7A-4821-B07E-410318028CA8Q33223969-20AC3476-24CC-43F9-B2E3-B998EEC94D33Q33415798-72BAB5EF-24A7-4681-9CB3-0FEE065569D4Q33683328-D7B7ABF0-AA28-4A39-A975-0C66FD56900EQ33850973-23E7FCE6-DD91-4F6E-9D23-DCCC96789C76Q33890912-B788CF33-EEE0-4F92-BC5D-633EDF1A38A4Q33911849-47246A1E-2194-4B1A-A544-9A7B9CC176B3Q33942231-6A018B1B-1EA8-4E22-9610-A0E70FEB9C42Q33946678-481E1EB2-FAB7-4A58-8C55-1CD2DDAA1BBDQ33961280-F04AEE1D-8B3F-44B8-BA0F-7461AB38C134Q34110093-BD89440B-EED1-4E52-A92A-7CD6542586F7Q34354324-8C45D9C4-FF7D-44A9-B8D4-D3877BD2FB8DQ34504961-2C37936E-81A6-4E91-AA78-8AF054AE3ACDQ34550922-4EA6C100-6B80-4AAC-922A-729BF9D7E2ACQ35083879-39E8B8FC-C413-453D-AC43-7115C5261E1CQ35105679-98262594-ACA9-470D-AFB8-5715C948D40CQ35600803-AAC61CA6-5BA4-482C-A495-44772545A093Q35745437-5772A52C-B9BF-4C6B-8193-F6EC594B1065Q35845424-086067EC-9F03-40A5-A672-7BCCB7EECB0EQ35847790-80FCDA11-9FE3-413B-B009-09B49DDDD298Q35896933-A7F62CD8-0D82-4C76-B567-AD0FCC2489C7Q35991137-1E0A665E-5A19-4007-80CD-556004312952Q36234765-06C6CC66-F366-44BC-BC0A-61E5BCEB9D92Q36276570-59E1B9FC-9B3D-4837-ACC6-D1813965DD83Q36499676-1070CF46-1149-4DF5-9A27-4D9F489A0BF7Q36655072-1E9F6E11-E57A-4163-A109-437BB1FC6176Q36669879-38CB92BF-8DE2-4B70-BF73-0EBF5265F16DQ36845470-44F396A9-A173-4925-AC03-408125BE2BF4Q36854921-DBCFD18B-8E91-4977-95B2-8BE951FA8BFBQ37152214-F985A5D8-3404-4E66-A745-3C547D9546FFQ37383714-E3805F33-7946-4A1B-960A-33C6774D777DQ37945208-6878E596-91E6-48C4-AB09-E3A3BA7B05B6Q38701188-94A9423D-09FA-4F79-B0AA-F2A6DB095254Q39505228-685CC343-C2C3-4319-A961-8008E6F72F87
P2860
Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sorting.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Phorbol ester-induced downregu ...... and altered endosomal sorting.
@en
Phorbol ester-induced downregu ...... and altered endosomal sorting.
@nl
type
label
Phorbol ester-induced downregu ...... and altered endosomal sorting.
@en
Phorbol ester-induced downregu ...... and altered endosomal sorting.
@nl
prefLabel
Phorbol ester-induced downregu ...... and altered endosomal sorting.
@en
Phorbol ester-induced downregu ...... and altered endosomal sorting.
@nl
P2860
P356
P1476
Phorbol ester-induced downregu ...... and altered endosomal sorting.
@en
P2093
Parsons IJ
Pelchen-Matthews A
P2860
P304
P356
10.1084/JEM.178.4.1209
P407
P50
P577
1993-10-01T00:00:00Z