Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts
about
Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cellsA novel chemotaxis assay in 3-D collagen gels by time-lapse microscopyComputational analysis of the spatiotemporal coordination of polarized PI3K and Rac1 activities in micro-patterned live cellsA mathematical model for neutrophil gradient sensing and polarizationPositive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cellsSpatial control of gene expression within a scaffold by localized inducer releaseEssential role of PDK1 in regulating endothelial cell migrationDecoupling polarization of the Golgi apparatus and GM1 in the plasma membraneFrom Physics to Pharmacology?Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanismSpontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblastsIntegrin signalling in directed cell migration.Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensing.Integrin-mediated protein kinase A activation at the leading edge of migrating cells.Open access microfluidic device for the study of cell migration during chemotaxis.Protein kinase A regulates 3-phosphatidylinositide dynamics during platelet-derived growth factor-induced membrane ruffling and chemotaxisCells navigate with a local-excitation, global-inhibition-biased excitable network.Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network.Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair.F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling.Directional persistence of cell migration coincides with stability of asymmetric intracellular signaling.A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.Signaling pathways that control cell migration: models and analysisAutologous morphogen gradients by subtle interstitial flow and matrix interactions.In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling.Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein.Nonadaptive regulation of ERK2 in Dictyostelium: implications for mechanisms of cAMP relaySystems biology in immunology: a computational modeling perspective.Quantitative models of signal transduction networks: How detailed should they be?Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cellMembrane-binding/modification model of signaling protein activation and analysis of its control by cell morphologyUse of virtual cell in studies of cellular dynamics.Activity of PLCε contributes to chemotaxis of fibroblasts towards PDGFCell population-based model of dermal wound invasion with heterogeneous intracellular signaling properties.PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by ErkDirectional sensing during chemotaxis.Phosphoinositide 3-kinases in cell migration.Directed cell migration in multi-cue environments.Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet.Receptor differential activation and cooperativity better explain cellular preference for different chemoattractant gradient shapes in an EGFR system.
P2860
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P2860
Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts
@en
Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts
@nl
type
label
Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts
@en
Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts
@nl
prefLabel
Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts
@en
Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts
@nl
P2860
P356
P1476
Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts
@en
P2093
Ian C Schneider
P2860
P304
P356
10.1083/JCB.200509028
P407
P577
2005-11-28T00:00:00Z