The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.
about
Evolution and origin of merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor geneA tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functionsMerlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleusRegulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancerMagicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2Pak1 and PIX regulate contact inhibition during epithelial wound healingSpatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 proteinThe biology and treatment of EML4-ALK non-small cell lung cancerThe tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressThe neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAPMouse models of neurofibromatosis 1 and 2.Neurofibromatosis type 2 protein, NF2: an uncoventional cell cycle regulator.Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressorMolecular conformation of the full-length tumor suppressor NF2/Merlin--a small-angle neutron scattering studyCyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerizationPAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signalingMerlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survivalThe future role of personalized medicine in the treatment of glioblastoma multiformeNF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctionsMixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelinationNeurofibromatosis type 2.Therapeutic potential of HSP90 inhibition for neurofibromatosis type 2.The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex.Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling.Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane.Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasmsLoss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells.Neurofibromatosis type 2 tumor suppressor protein, NF2, induces proteasome-mediated degradation of JC virus T-antigen in human glioblastomaUpdate on meningiomas.AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas.Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells.Phosphorylation of merlin regulates its stability and tumor suppressive activity.Laminin is required for Schwann cell morphogenesisPAK kinase regulates Rac GTPase and is a potential target in human schwannomasThe NF2 tumor suppressor regulates microtubule-based vesicle trafficking via a novel Rac, MLK and p38(SAPK) pathway.Fluorescence resonance energy transfer analysis of merlin conformational changes.Comprehensive pharmacological profiling of neurofibromatosis cell lines.The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression
P2860
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P2860
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.
@en
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.
@nl
type
label
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.
@en
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.
@nl
prefLabel
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.
@en
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.
@nl
P2093
P1433
P1476
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling
@en
P2093
A I McClatchey
J P O'Bryan
P356
10.1016/S1534-5807(01)00009-0
P407
P50
P577
2001-07-01T00:00:00Z