Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).
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CrkII participation in the cellular effects of growth hormone and insulin-like growth factor-1. Phosphatidylinositol-3 kinase dependent and independent effectsSeptins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activationAspirin inhibits serine phosphorylation of insulin receptor substrate 1 in growth hormone treated animalsUCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drugC3G-mediated suppression of oncogene-induced focus formation in fibroblasts involves inhibition of ERK activation, cyclin A expression and alterations of anchorage-independent growth.c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase.Growth hormone pathways signaling for cell proliferation and survival in hippocampal neural precursors from postnatal mice.YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.The mechanism of effect of growth hormone on preadipocyte and adipocyte function.Inhibitory GH receptor extracellular domain monoclonal antibodies: three-dimensional epitope mappingThe p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomicsJAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells.Research resource: identification of novel growth hormone-regulated phosphorylation sites by quantitative phosphoproteomics.Role of the cytokine-induced SH2 domain-containing protein CIS in growth hormone receptor internalization.Anchorage-independent phosphorylation of p130(Cas) protects lung adenocarcinoma cells from anoikis.Disulfide linkage of growth hormone (GH) receptors (GHR) reflects GH-induced GHR dimerization. Association of JAK2 with the GHR is enhanced by receptor dimerization.Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor.Src-CrkII-C3G-dependent activation of Rap1 switches growth hormone-stimulated p44/42 MAP kinase and JNK/SAPK activities.SH2-B is required for growth hormone-induced actin reorganization.UCS15A, a non-kinase inhibitor of Src signal transduction.Activation of GH signaling and GH-independent stimulation of growth in zebrafish by introduction of a constitutively activated GHR construct.
P2860
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P2860
Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Growth hormone stimulates the ...... gnaling complex involving p130
@nl
Growth hormone stimulates the ...... ted protein kinase (JNK/SAPK).
@en
type
label
Growth hormone stimulates the ...... gnaling complex involving p130
@nl
Growth hormone stimulates the ...... ted protein kinase (JNK/SAPK).
@en
prefLabel
Growth hormone stimulates the ...... gnaling complex involving p130
@nl
Growth hormone stimulates the ...... ted protein kinase (JNK/SAPK).
@en
P2093
P2860
P356
P1476
Growth hormone stimulates the ...... ted protein kinase (JNK/SAPK).
@en
P2093
P2860
P304
33864-33875
P356
10.1074/JBC.273.50.33864
P407
P577
1998-12-01T00:00:00Z