Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment.
about
Function, regulation and pathological roles of the Gab/DOS docking proteinsThe major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signalingSelective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphataseFunctional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signalingThe adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factorsp140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activityThe SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motilityPTP-1B is an essential positive regulator of platelet integrin signalingA novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activationInterferon-gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytesProtein tyrosine phosphatases expression during development of mouse superior colliculusThe Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by TrypanosomatidsRegulation of Endothelial Adherens Junctions by Tyrosine PhosphorylationShp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defectsProtein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor KinaseCsk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activationRegulation of cell adhesion by protein-tyrosine phosphatases. I. Cell-matrix adhesionProtein tyrosine phosphatases and the immune responsePhosphorylation site dynamics of early T-cell receptor signalingT-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiationC-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases.Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signalingNovel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling.SSeCKS/Gravin/AKAP12 attenuates expression of proliferative and angiogenic genes during suppression of v-Src-induced oncogenesisTyrosine phosphatases such as SHP-2 act in a balance with Src-family kinases in stabilization of postsynaptic clusters of acetylcholine receptors.The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancer.Deletion of Shp2 in bronchial epithelial cells impairs IL-25 production in vitro, but has minor influence on asthmatic inflammation in vivo.Rationale and preclinical efficacy of a novel anti-EMP2 antibody for the treatment of invasive breast cancer.Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuriaSprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development.Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling.Substrate specificity of protein tyrosine phosphatases 1B, RPTPα, SHP-1, and SHP-2.Src-dependent ezrin phosphorylation in adhesion-mediated signalingIntracellular reactive oxygen species activate Src tyrosine kinase during cell adhesion and anchorage-dependent cell growthArecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activationSHP2E76K mutant promotes lung tumorigenesis in transgenic micePZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice.The nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling.CB₁ cannabinoid receptors promote maximal FAK catalytic activity by stimulating cooperative signaling between receptor tyrosine kinases and integrins in neuronal cells.Activation of Lyn tyrosine kinase through decreased membrane cholesterol levels during a change in its membrane distribution upon cell detachment.
P2860
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P2860
Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Shp2 regulates SRC family kina ...... y controlling Csk recruitment.
@en
Shp2 regulates SRC family kina ...... y controlling Csk recruitment.
@nl
type
label
Shp2 regulates SRC family kina ...... y controlling Csk recruitment.
@en
Shp2 regulates SRC family kina ...... y controlling Csk recruitment.
@nl
prefLabel
Shp2 regulates SRC family kina ...... y controlling Csk recruitment.
@en
Shp2 regulates SRC family kina ...... y controlling Csk recruitment.
@nl
P2093
P1433
P1476
Shp2 regulates SRC family kina ...... y controlling Csk recruitment.
@en
P2093
Benjamin G Neel
Burkhart L Schraven
Gengyun Wen
Jincai Luo
Julie A Thompson
Maria I Kontaridis
Mark R Philips
Si Qing Zhang
Toshiyuki Araki
Trever G Bivona
P304
P356
10.1016/S1097-2765(04)00050-4
P577
2004-02-01T00:00:00Z