about
In vitro affinity of piribedil for dopamine D3 receptor subtypes, an autoradiographic studyThe molecular assembly of amyloid aβ controls its neurotoxicity and binding to cellular proteinsExpression of AMPA and NMDA receptor subunits in the cervical spinal cord of wobbler miceProteomic profiling of cervical and lumbar spinal cord reveals potential protective mechanisms in the wobbler mouse, a model of motor neuron degeneration.Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.Multifunctional liposomes reduce brain β-amyloid burden and ameliorate memory impairment in Alzheimer's disease mouse models.The peculiar role of the A2V mutation in amyloid-β (Aβ) 1-42 molecular assemblyThe new β amyloid-derived peptide Aβ1-6A2V-TAT(D) prevents Aβ oligomer formation and protects transgenic C. elegans from Aβ toxicity.Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosisTackling amyloidogenesis in Alzheimer's disease with A2V variants of Amyloid-β.Clusterin Binds to Aβ1-42 Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation.Good gene, bad gene: new APP variant may be both.Investigation of Functionalized Poly(N,N-dimethylacrylamide)-block-polystyrene Nanoparticles As Novel Drug Delivery System to Overcome the Blood-Brain Barrier In Vitro.The hunt for brain Aβ oligomers by peripherally circulating multi-functional nanoparticles: Potential therapeutic approach for Alzheimer disease.Mono and dually decorated nanoliposomes for brain targeting, in vitro and in vivo studies.Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model.Dimethyl sulfoxide: an antagonist in scintillation proximity assay [(35)S]-GTPgammaS binding to rat 5-HT(6) receptor cloned in HEK-293 cells?Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.Specific recognition of biologically active amyloid-β oligomers by a new surface plasmon resonance-based immunoassay and an in vivo assay in Caenorhabditis elegans.Neuronal hyperexcitability and seizures are associated with changes in glial-neuronal interactions in the hippocampus of a mouse model of epilepsy with mental retardation.Neural precursor-derived astrocytes of wobbler mice induce apoptotic death of motor neurons through reduced glutamate uptake.Overcoming synthetic Abeta peptide aging: a new approach to an age-old problem.Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.High affinity and selectivity of [[(arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone derivatives for the 5-HT(1A) receptor. Synthesis and structure-affinity relationships.Design, synthesis and binding properties of novel and selective 5-HT3 and 5-HT4 receptor ligands.1,5-Benzodiazepine tricyclic derivatives exerting anti-inflammatory effects in mice by inhibiting interleukin-6 and prostaglandinE(2)production.[1,2,4]Triazole derivatives as 5-HT(1A) serotonin receptor ligands.Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes.Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo.Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.Synthesis and binding properties of novel selective 5-HT3 receptor ligands.Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect Aβ aggregation features and cross the blood-brain-barrier: implications for therapy of Alzheimer disease.Tetrahydro-β-carboline-based spirocyclic lactam as type II' β-turn: application to the synthesis and biological evaluation of somatostatine mimetics.Interactions of the prion peptide (PrP 106-126) with brain capillary endothelial cells: coordinated cell killing and remodeling of intercellular junctions.Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.Synthesis of 3-arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as novel, potent, and selective alpha1-adrenoceptor ligands.Neuroprotection with the CXCL8 inhibitor repertaxin in transient brain ischemia.Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.
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P50
description
hulumtues
@sq
researcher
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ricercatore
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wetenschapper
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հետազոտող
@hy
name
Alfredo Cagnotto
@ast
Alfredo Cagnotto
@en
Alfredo Cagnotto
@es
Alfredo Cagnotto
@nl
type
label
Alfredo Cagnotto
@ast
Alfredo Cagnotto
@en
Alfredo Cagnotto
@es
Alfredo Cagnotto
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prefLabel
Alfredo Cagnotto
@ast
Alfredo Cagnotto
@en
Alfredo Cagnotto
@es
Alfredo Cagnotto
@nl
P106
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7003385754
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5482147425862145040005
P31
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0000-0002-1390-8240
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viaf-5482147425862145040005