Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency.
about
Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment.Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease.Production of an anti-Aβ antibody fragment in Pichia pastoris and in vitro and in vivo validation of its therapeutic effect.Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils.A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers.Effects of an Aβ-antibody fragment on Aβ aggregation and astrocytic uptake are modulated by apolipoprotein E and J mimetic peptides.Towards the improvement in stability of an anti-Aβ single-chain variable fragment, scFv-h3D6, as a way to enhance its therapeutic potential.Understanding the contribution of disulfide bridges to the folding and misfolding of an anti-Aβ scFv.
P2860
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P2860
Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Elongation of the C-terminal d ...... ases its aggregation tendency.
@en
Elongation of the C-terminal d ...... ases its aggregation tendency.
@nl
type
label
Elongation of the C-terminal d ...... ases its aggregation tendency.
@en
Elongation of the C-terminal d ...... ases its aggregation tendency.
@nl
prefLabel
Elongation of the C-terminal d ...... ases its aggregation tendency.
@en
Elongation of the C-terminal d ...... ases its aggregation tendency.
@nl
P2093
P2860
P356
P1476
Elongation of the C-terminal d ...... ases its aggregation tendency.
@en
P2093
Baldo Oliva
Bernat Blasco-Moreno
Geovanny Rivera-Hernández
Marta Marin-Argany
P2860
P304
P356
10.4161/MABS.25382
P577
2013-06-19T00:00:00Z