about
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cellsIdentification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cellsS100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells.Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression.Lack of neuroprotection by heat shock protein 70 overexpression in a mouse model of global cerebral ischemia.A comprehensive siRNA screen for kinases that suppress macroautophagy in optimal growth conditions.Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance.Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.S100 and annexin proteins identify cell membrane damage as the Achilles heel of metastatic cancer cells.Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.Repurposing Cationic Amphiphilic Antihistamines for Cancer TreatmentDihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization.Annexins are instrumental for efficient plasma membrane repair in cancer cells.Methods for Probing Lysosomal Membrane Permeabilization.Quantification of Lysosomal Membrane Permeabilization by Cytosolic Cathepsin and β-N-Acetyl-Glucosaminidase Activity Measurements.A Method to Monitor Lysosomal Membrane Permeabilization by Immunocytochemistry.Visualizing Lysosomal Membrane Permeabilization by Fluorescent Dextran Release.Annexins in plasma membrane repair.Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase.ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression.ErbB2-associated changes in the lysosomal proteome.NBCn1 and NHE1 expression and activity in DeltaNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance.Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.BAMLET activates a lysosomal cell death program in cancer cells.Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation.Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation.Heat shock protein 70 inhibits shrinkage-induced programmed cell death via mechanisms independent of effects on cell volume-regulatory membrane transport proteins.Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms.Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair.Quantitative Profiling of Lysosomal Lipidome by Shotgun Lipidomics.Liprotides kill cancer cells by disrupting the plasma membrane.Methods for the quantification of lysosomal membrane permeabilization: a hallmark of lysosomal cell death.Using Liprotides to Deliver Cholesterol to the Plasma Membrane.Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine.Annexins induce curvature on free-edge membranes displaying distinct morphologies.Annexin A7 is required for ESCRT III-mediated plasma membrane repairCalcium electroporation and electrochemotherapy for cancer treatment: Importance of cell membrane composition investigated by lipidomics, calorimetry and in vitro efficacyExpression of a p16INK4a-specific ribozyme downmodulates p16INK4a abundance and accelerates cell proliferationExtracellular heat shock protein 70: a potential prognostic marker for chronic myeloid leukemia
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Jesper Nylandsted
@ast
Jesper Nylandsted
@en
Jesper Nylandsted
@es
Jesper Nylandsted
@nl
Jesper Nylandsted
@sl
type
label
Jesper Nylandsted
@ast
Jesper Nylandsted
@en
Jesper Nylandsted
@es
Jesper Nylandsted
@nl
Jesper Nylandsted
@sl
prefLabel
Jesper Nylandsted
@ast
Jesper Nylandsted
@en
Jesper Nylandsted
@es
Jesper Nylandsted
@nl
Jesper Nylandsted
@sl
P106
P1153
6602765251
P21
P31
P496
0000-0001-6474-5093