about
Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Δ2-isoxazoline derivatives as potent and selective agonists of α7 nicotinic acetylcholine receptors.The allosteric vestibule of a seven transmembrane helical receptor controls G-protein couplingA novel spirocyclic tropanyl-Δ²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake.Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity.Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype.New spirocyclic Δ²-isoxazoline derivatives related to selective agonists of α7 neuronal nicotinic acetylcholine receptors.Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor.Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes.Design of novel alpha7-subtype-preferring nicotinic acetylcholine receptor agonists: application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies.On the selection of an opioid for local skin analgesia: Structure-skin permeability relationships.Investigating the hydrogen-bond acceptor site of the nicotinic pharmacophore model: a computational and experimental study using epibatidine-related molecular probes.Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.Identification of α7 Nicotinic Acetylcholine Receptor Silent Agonists Based on the Spirocyclic Quinuclidine-Δ2 -Isoxazoline Scaffold: Synthesis and Electrophysiological Evaluation.Involvement of α7 nAChR subtype in rat oxaliplatin-induced neuropathy: effects of selective activation.In vivo and in vitro ADMET profiling and in vivo pharmacodynamic investigations of a selective α7 nicotinic acetylcholine receptor agonist with a spirocyclic Δ2-isoxazoline molecular skeleton.A New Molecular Mechanism To Engineer Protean Agonism at a G Protein-Coupled Receptor.Allosteric Modulation of Alpha7 Nicotinic Receptors: Mechanistic Insight through Metadynamics and Essential Dynamics.Bifunctional compounds targeting both D2 and non-α7 nACh receptors: design, synthesis and pharmacological characterization.Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M1 and M2The enantiomers of epiboxidine and of two related analogs: Synthesis and estimation of their binding affinity at α4β2 and α7 neuronal nicotinic acetylcholine receptorsA convenient synthesis of 4-(2-hydroxyethyl)indolin-2-one, a useful intermediate for the preparation of both dopamine receptor agonists and protein kinase inhibitorsPhotoswitchable Antimetabolite for Targeted Photoactivated ChemotherapyNovel 5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazoles to investigate the activation of the α7 nicotinic acetylcholine receptor subtype: Synthesis and electrophysiological evaluationSynthesis and binding affinity at α4β2 and α7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring systemActivation of M2 muscarinic acetylcholine receptors by a hybrid agonist enhances cytotoxic effects in GB7 glioblastoma cancer stem cellsTotal syntheses of anominine and tubingensin AA Small Library of 1,2,3-Triazole Analogs of CAP-55: Synthesis and Binding Affinity at Nicotinic Acetylcholine ReceptorsOptical Control of Cardiac Function with a Photoswitchable Muscarinic AgonistThe novel hybrid agonist HyNDA-1 targets the D3R-nAChR heteromeric complex in dopaminergic neuronsFluorination of Photoswitchable Muscarinic Agonists Tunes Receptor Pharmacology and Photochromic Properties
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P50
description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Carlo Matera
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Carlo Matera
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Carlo Matera
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Carlo Matera
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Carlo Matera
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type
label
Carlo Matera
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Carlo Matera
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Carlo Matera
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Carlo Matera
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Carlo Matera
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Carlo Matera
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Carlo Matera
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Carlo Matera
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Carlo Matera
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Carlo Matera
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P1053
G-3808-2015
P106
P1153
24468276900
P21
P31
P3829
P496
0000-0001-6939-3859