about
A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance.Somatostatin and its receptors from fish to mammals.Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed miceDifferential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.Role of endogenous cortistatin in the regulation of ghrelin system expression at pancreatic level under normal and obese conditions.Melatonin regulates somatotrope and lactotrope function through common and distinct signaling pathways in cultured primary pituitary cells from female primatesObesity alters gene expression for GH/IGF-I axis in mouse mammary fat pads: differential role of cortistatin and somatostatin.Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomasKisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanismsRole of ghrelin system in neuroprotection and cognitive functions: implications in Alzheimer's disease.Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner.Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin.Homologous and heterologous in vitro regulation of pituitary receptors for somatostatin, growth hormone (GH)-releasing hormone, and ghrelin in a nonhuman primate (Papio anubis).Does the pituitary somatotrope play a primary role in regulating GH output in metabolic extremes?In1-ghrelin, a splice variant of ghrelin gene, is associated with the evolution and aggressiveness of human neuroendocrine tumors: Evidence from clinical, cellular and molecular parametersIn1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features.The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female miceLack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode.Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors.Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth hormone and insulin release in mice.Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity?Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice.Understanding the multifactorial control of growth hormone release by somatotropes: lessons from comparative endocrinology.The truncated isoform of somatostatin receptor5 (sst5TMD4) is associated with poorly differentiated thyroid cancer.Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in β-cell mass.BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas.The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients.Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight.Ghrelin O-acyltransferase (GOAT) enzyme is overexpressed in prostate cancer, and its levels are associated with patient's metabolic status: Potential value as a non-invasive biomarker.The components of somatostatin and ghrelin systems are altered in neuroendocrine lung carcinoids and associated to clinical-histological features.Metformin Reduces Prostate Tumor Growth, in a Diet-Dependent Manner, by Modulating Multiple Signaling Pathways.The expression of the truncated isoform of somatostatin receptor subtype 5 associates with aggressiveness in medullary thyroid carcinoma cells.Role of the Kiss1/Kiss1r system in the regulation of pituitary cell function.Models of GH deficiency in animal studies.Identification of a mouse ghrelin gene transcript that contains intron 2 and is regulated in the pituitary and hypothalamus in response to metabolic stress.Obesity and metabolic dysfunction severely influence prostate cell function: role of insulin and IGF1.The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressivenessIslet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Manuel D. Gahete
@ast
Manuel D. Gahete
@en
Manuel D. Gahete
@es
Manuel D. Gahete
@nl
Manuel D. Gahete
@sl
type
label
Manuel D. Gahete
@ast
Manuel D. Gahete
@en
Manuel D. Gahete
@es
Manuel D. Gahete
@nl
Manuel D. Gahete
@sl
prefLabel
Manuel D. Gahete
@ast
Manuel D. Gahete
@en
Manuel D. Gahete
@es
Manuel D. Gahete
@nl
Manuel D. Gahete
@sl
P1053
C-4969-2009
P106
P1153
35271831100
P21
P31
P3829
P496
0000-0002-4578-2179