about
Regulation of the cardiac sodium pumpStructure ofStaphylococcus aureus1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in complex with acetoacetyl-CoADiscovery of potent pteridine reductase inhibitors to guide antiparasite drug developmentSulphate removal induces a major conformational change in Leishmania mexicana pyruvate kinase in the crystalline stateOne Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual ScreeningStructure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the LeishmaniasesHigh-resolution structures ofTrypanosoma bruceipteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug targetStructure of recombinantLeishmania donovanipteridine reductase reveals a disordered active siteA separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscleDesign, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis.Diversity oriented syntheses of fused pyrimidines designed as potential antifolates.Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors.The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation.Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors.Regulation of the cardiac Na(+) pump by palmitoylation of its catalytic and regulatory subunits.Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate.The trypanosome alternative oxidase: a potential drug target?Simplifying nature: Towards the design of broad spectrum kinetoplastid inhibitors, inspired by acetogenins.Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues.Robust neutralising activity and activation of neutrophil cytotoxic responses mediated by antibodies targeting the HTLV-1 envelope glycoprotein.Design and Synthesis of Broad Spectrum Trypanosomatid Selective Inhibitors.Direct and indirect approaches to identify drug modes of action.Greasing the wheels or a spanner in the works? Regulation of the cardiac sodium pump by palmitoylation.Structure-Based Design, Synthesis and Biological Evaluation of Bis-Tetrahydropyran Furan Acetogenin Mimics Targeting the Trypanosomatid F1 Component of ATP Synthase
P50
Q27002929-5DAB9D3F-D722-40CF-87AC-38CBD34DDB73Q27649078-73E21A69-F374-449C-B2F1-C4944D127012Q27649767-D9AD4621-4154-4B74-9096-EFB15E751132Q27652018-8DA6E39C-1171-414E-B2A8-436532FA9763Q27655956-0EE7BDB9-4C33-43A7-9295-2FF7E757271FQ27658197-3B581689-FAF3-4B56-9424-926880E4B41CQ27666140-4565AC8B-6E10-4943-9454-CFCE682E0D2BQ27666482-7E249350-CEFC-43EC-85D4-BAD5BC87A282Q28576712-305A5360-4ABC-4CE0-BF7E-D5746DCD749BQ33326935-868B5EF8-70D5-41A3-82C8-6EEFD73B8F6CQ33480534-AB39E6ED-958B-4A81-8A8F-5572F12585C7Q34982034-FCF68343-5BAF-44DF-BB90-1BD77DA96493Q35372391-E0246432-730C-4867-A4AA-93821E79542DQ37417651-4A15CDD3-4D88-47BB-A0CA-728980C98A5FQ38077214-3D7ACBF6-1A9F-4D97-A4DD-A0D8A45E8306Q38784214-A5EE8EFF-6759-4959-B6E2-3547555BA6E3Q38789787-D4624FD2-017A-40C0-BDD8-DDD90B4C2213Q39030155-44D242C8-6BB3-49F9-B86B-996D0ED7794AQ42242216-9CF17CC4-E3A0-4EA5-A357-78F868CD4598Q46273764-CEF6383B-D8EF-45EB-88A7-F8184CD4B8F4Q47219548-EAC2C0BD-ED21-405B-8BDE-366D6F438FE6Q48169839-73D4338A-040A-4CF9-8808-32719E0C9B89Q50102694-338EF898-AB03-4793-8472-04941753841EQ90618360-4B08E1FA-7156-40D3-83D6-38B6CD25D844
P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Lindsay Tulloch
@ast
Lindsay Tulloch
@en
Lindsay Tulloch
@es
Lindsay Tulloch
@nl
Lindsay Tulloch
@sl
type
label
Lindsay Tulloch
@ast
Lindsay Tulloch
@en
Lindsay Tulloch
@es
Lindsay Tulloch
@nl
Lindsay Tulloch
@sl
prefLabel
Lindsay Tulloch
@ast
Lindsay Tulloch
@en
Lindsay Tulloch
@es
Lindsay Tulloch
@nl
Lindsay Tulloch
@sl
P108
P106
P31
P3835
lindsay-tulloch2
P496
0000-0001-7223-5106