The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site.
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Crystal structure of a bacterial homologue of the kidney urea transporterAntidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structuresMonoamine transporters: insights from molecular dynamics simulationsThe SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunctionVisualizing functional motions of membrane transporters with molecular dynamics simulationsBehavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporterNonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substratesSpontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminusA steered molecular dynamics study of binding and translocation processes in the GABA transporterA conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state.Complete mapping of substrate translocation highlights the role of LeuT N-terminal segment in regulating transport cycleModeling and dynamics of the inward-facing state of a Na+/Cl- dependent neurotransmitter transporter homologueStructure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family TransporterA competitive inhibitor traps LeuT in an open-to-out conformation.Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformationSubstrate specificity and ion coupling in the Na+/betaine symporter BetPCrystal structure of a phosphorylation-coupled saccharide transporterSubstrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologueInsights into transport mechanism from LeuT engineered to transport tryptophanX-ray structures of LeuT in substrate-free outward-open and apo inward-open statesStructures of LeuT in bicelles define conformation and substrate binding in a membrane-like contextStructural basis of the alternating-access mechanism in a bile acid transporterThe atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitorsLigand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulationsMapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular DynamicsSugar binding residue affects apparent Na+ affinity and transport stoichiometry in mouse sodium/glucose cotransporter type 3BRole of Annular Lipids in the Functional Properties of Leucine Transporter LeuT ProteomicellesDirect assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMRConformational Changes in Two Inter-Helical Loops of Mhp1 Membrane Transporter.Molecular simulations elucidate the substrate translocation pathway in a glutamate transporter.Insights from molecular dynamics: the binding site of cocaine in the dopamine transporter and permeation pathways of substrates in the leucine and dopamine transporters.Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood.Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters.Beyond non-integer Hill coefficients: A novel approach to analyzing binding data, applied to Na+-driven transporters.Receptor-Based Discovery of a Plasmalemmal Monoamine Transporter Inhibitor via High Throughput Docking and Pharmacophore Modeling.Substrate-dependent proton antiport in neurotransmitter:sodium symporters.Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter.Conformational dynamics of ligand-dependent alternating access in LeuT.Not just an oil slick: how the energetics of protein-membrane interactions impacts the function and organization of transmembrane proteins.
P2860
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P2860
The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The mechanism of a neurotransm ...... rate in a second binding site.
@en
The mechanism of a neurotransm ...... rate in a second binding site.
@nl
type
label
The mechanism of a neurotransm ...... rate in a second binding site.
@en
The mechanism of a neurotransm ...... rate in a second binding site.
@nl
prefLabel
The mechanism of a neurotransm ...... rate in a second binding site.
@en
The mechanism of a neurotransm ...... rate in a second binding site.
@nl
P2093
P2860
P1433
P1476
The mechanism of a neurotransm ...... rate in a second binding site.
@en
P2093
Harel Weinstein
Jonathan A Javitch
Matthias Quick
Yongfang Zhao
P2860
P304
P356
10.1016/J.MOLCEL.2008.05.008
P577
2008-06-01T00:00:00Z