Metabolism of 1'- and 4-hydroxymidazolam by glucuronide conjugation is largely mediated by UDP-glucuronosyltransferases 1A4, 2B4, and 2B7.
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Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C DiseaseMechanistic Modeling to Predict Midazolam Metabolite Exposure from In Vitro Data.Determination of major UDP-glucuronosyltransferase enzymes and their genotypes responsible for 20-HETE glucuronidation.Midazolam microdose to determine systemic and pre-systemic metabolic CYP3A activity in humans.Pharmacokinetic Drug Interaction Studies with Enzalutamide.Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers.Regioselective biotransformation of CNS drugs and its clinical impact on adverse drug reactions.Transcriptional regulation of human UDP-glucuronosyltransferase genes.Software-aided cytochrome P450 reaction phenotyping and kinetic analysis in early drug discovery.Hypoalbuminaemia and decreased midazolam clearance in terminally ill adult patients, an inflammatory effect?In vitro studies on flubromazolam metabolism and detection of its metabolites in authentic forensic samples.Pharmacokinetics cannot explain the increased effective dose requirement for morphine and midazolam in rats during their extended administration alone or in combination.Evidence of CYP3A allosterism in vivo: analysis of interaction between fluconazole and midazolam.Humanizing the zebrafish liver shifts drug metabolic profiles and improves pharmacokinetics of CYP3A4 substrates.Species differences and substrate specificity of CYP3A heteroactivation by efavirenz.Pharmacokinetics of ginkgolides A, B and K after single and multiple intravenous infusions and their interactions with midazolam in healthy Chinese male subjects.Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers.CYP3A5*3 and bilirubin predict midazolam population pharmacokinetics in Asian cancer patients.Microbial production of phase I and phase II metabolites of midazolam.Prolonged sedation of lorazepam due to absent UGT2B4/2B7 glucuronidation.
P2860
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P2860
Metabolism of 1'- and 4-hydroxymidazolam by glucuronide conjugation is largely mediated by UDP-glucuronosyltransferases 1A4, 2B4, and 2B7.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Metabolism of 1'- and 4-hydrox ...... ransferases 1A4, 2B4, and 2B7.
@en
Metabolism of 1'- and 4-hydrox ...... ransferases 1A4, 2B4, and 2B7.
@nl
type
label
Metabolism of 1'- and 4-hydrox ...... ransferases 1A4, 2B4, and 2B7.
@en
Metabolism of 1'- and 4-hydrox ...... ransferases 1A4, 2B4, and 2B7.
@nl
prefLabel
Metabolism of 1'- and 4-hydrox ...... ransferases 1A4, 2B4, and 2B7.
@en
Metabolism of 1'- and 4-hydrox ...... ransferases 1A4, 2B4, and 2B7.
@nl
P2093
P356
P1476
Metabolism of 1'- and 4-hydrox ...... ransferases 1A4, 2B4, and 2B7.
@en
P2093
Chang Soo Choi
Jae-Gook Shin
Kwang-Hyeon Liu
Kyung-Ah Seo
Soo Kyung Bae
Young-Kil Choi
P304
P356
10.1124/DMD.110.035295
P577
2010-08-16T00:00:00Z