Obesity up-regulates intermediate conductance calcium-activated potassium channels and myoendothelial gap junctions to maintain endothelial vasodilator function.
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Preserved Microvascular Endothelial Function in Young, Obese Adults with Functional Loss of Nitric Oxide Signaling.Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanismsDietary obesity increases NO and inhibits BKCa-mediated, endothelium-dependent dilation in rat cremaster muscle artery: association with caveolins and caveolae.Prenatal testosterone induces sex-specific dysfunction in endothelium-dependent relaxation pathways in adult male and female ratsElevated testosterone levels during rat pregnancy cause hypersensitivity to angiotensin II and attenuation of endothelium-dependent vasodilation in uterine arteriesVascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesisUpregulation of SK3 and IK1 channels contributes to the enhanced endothelial calcium signaling and the preserved coronary relaxation in obese Zucker rats.Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice.Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions?Diminished neurogenic femoral artery vasoconstrictor response in a Zucker obese rat model: differential regulation of NOS and COX derivatives.Small lipid-binding proteins in regulating endothelial and vascular functions: focusing on adipocyte fatty acid binding protein and lipocalin-2.Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity.Enalapril Normalizes Endothelium-Derived Hyperpolarizing Factor-Mediated Relaxation in Mesenteric Artery of Adult Hypertensive Rats Prenatally Exposed to Testosterone.Endothelium-Derived Hyperpolarization and Coronary Vasodilation: Diverse and Integrated Roles of Epoxyeicosatrienoic Acids, Hydrogen Peroxide, and Gap Junctions.Developmental conditioning of endothelium-derived hyperpolarizing factor-mediated vasorelaxationKCa 3.1 channels maintain endothelium-dependent vasodilatation in isolated perfused kidneys of spontaneously hypertensive rats after chronic inhibition of NOS.Western-style diet modulates contractile responses to phenylephrine differently in mesenteric arteries from senescence-accelerated prone (SAMP8) and resistant (SAMR1) mice.KCa 3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stressLeptin and the regulation of endothelial function in physiological and pathological conditions.Myoendothelial contacts, gap junctions, and microdomains: anatomical links to function?Endothelial control of vasodilation: integration of myoendothelial microdomain signalling and modulation by epoxyeicosatrienoic acids.The microvasculature: a target for nutritional programming and later risk of cardio-metabolic disease.Developmental conditioning of the vasculature.Vascular structural and functional changes: their association with causality in hypertension: models, remodeling and relevance.Calcium and electrical signaling in arterial endothelial tubes: New insights into cellular physiology and cardiovascular function.'Altered' mesenteric artery SK(Ca) : functional implications?Decreased EDHF-mediated relaxation is a major mechanism in endothelial dysfunction in resistance arteries in aged mice on prolonged high-fat sucrose diet.Impact of Aging on Calcium Signaling and Membrane Potential in Endothelium of Resistance Arteries: A Role for Mitochondria.Increased myoendothelial feedback is associated with increased connexin37 and IK1 channel expression in mesenteric arteries of diet-induced hyperhomocysteinemic mice.Preserved regulation of renal perfusion pressure by small and intermediate conductance KCa channels in hypertensive mice with or without renal failure.The microcirculation: a target for developmental priming.Less is more: minimal expression of myoendothelial gap junctions optimizes cell-cell communication in virtual arterioles.Pregnancy-induced remodelling and enhanced endothelium-derived hyperpolarization-type vasodilator activity in rat uterine radial artery: transient receptor potential vanilloid type 4 channels, caveolae and myoendothelial gap junctions.Increased caveolae density and caveolin-1 expression accompany impaired NO-mediated vasorelaxation in diet-induced obesity
P2860
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P2860
Obesity up-regulates intermediate conductance calcium-activated potassium channels and myoendothelial gap junctions to maintain endothelial vasodilator function.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Obesity up-regulates intermedi ...... othelial vasodilator function.
@en
Obesity up-regulates intermedi ...... othelial vasodilator function.
@nl
type
label
Obesity up-regulates intermedi ...... othelial vasodilator function.
@en
Obesity up-regulates intermedi ...... othelial vasodilator function.
@nl
prefLabel
Obesity up-regulates intermedi ...... othelial vasodilator function.
@en
Obesity up-regulates intermedi ...... othelial vasodilator function.
@nl
P2093
P50
P921
P356
P1476
Obesity up-regulates intermedi ...... othelial vasodilator function.
@en
P2093
Lauren Howitt
Preet S Chadha
T Hilton Grayson
Tim V Murphy
P304
P356
10.1124/JPET.110.167593
P407
P577
2010-07-29T00:00:00Z