about
Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductasesThe CD46-Jagged1 interaction is critical for human TH1 immunityThe structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalphaStructural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.Structural and Functional Studies on the N-terminal Domain of the Shigella Type III Secretion Protein MxiGCrystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc RICa2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin EConformational plasticity at the IgE-binding site of the B-cell receptor CD23Human immunoglobulin E flexes between acutely bent and extended conformations.Solution structure and dynamics of the bioactive retroviral M domain from Rous sarcoma virusIgE binds asymmetrically to its B cell receptor CD23Recombinant complement receptor 2 radiolabeled with [99mTc(CO)3]+: a potential new radiopharmaceutical for imaging activated complementValidating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approachesSoluble CD23 controls IgE synthesis and homeostasis in human B cells.Exploiting structural principles to design cyclin-dependent kinase inhibitors.The intrinsic flexibility of IgE and its role in binding FcepsilonRI.Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class.Ontogeny of human IgE-expressing B cells and plasma cellsAntibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps.Inhibitors of MDM2 and MDMX: a structural perspective.The key role of protein flexibility in modulating IgE interactions.MDM2-p53 protein-protein interaction inhibitors: a-ring substituted isoindolinones.Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency.Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy.Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3.The structure of human CD23 and its interactions with IgE and CD21.NMR determination that an extended BH3 motif of pro-apoptotic BID is specifically bound to BCL-XL.Catalytic folding of the Cepsilon3 domain by its high affinity receptor.Identification of Contact Residues in the IgE Binding Site of Human FcεRIα†Solution Structures of FcεRI α-Chain Mimics: A β-Hairpin Peptide and Its RetroenantiomerAllergen specificity of IgG4-expressing B cells in patients with grass pollen allergy undergoing immunotherapyStructure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptorA Mass-Spectrometry-Based Modelling Workflow for Accurate Prediction of IgG Antibody Conformations in the Gas Phase.Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibodyCalreticulin binding affinity for glycosylated lamininCross-reactivity of antiidiotypic antibodies with DNA in systemic lupus erythematosusStructural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptideBasis of the intrinsic flexibility of the Cε3 domain of IgENMR backbone assignment of the Cε4 domain of immunoglobulin E
P50
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P50
description
immunologist
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wetenschapper
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name
James M. McDonnell
@ast
James M. McDonnell
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James M. McDonnell
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James M. McDonnell
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James M. McDonnell
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type
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James M. McDonnell
@ast
James M. McDonnell
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James M. McDonnell
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James M. McDonnell
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James M. McDonnell
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James McDonnell
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James M. McDonnell
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James M. McDonnell
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James M. McDonnell
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James M. McDonnell
@nl
James M. McDonnell
@sl
P106
P1153
7101838569
P21
P31
P496
0000-0001-9037-2980