The integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking.
about
Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteinsCloning and expression of mouse legumain, a lysosomal endopeptidaseMolecular cloning, characterization of cDNA, and distribution of mRNA encoding the frog prohormone convertase PC1.Specificity of the dynorphin-processing endoprotease: comparison with prohormone convertases.A look at the Caenorhabditis elegans Kex2/Subtilisin-like proprotein convertase family.The transmembrane domain of the prohormone convertase PC3: a key motif for targeting to the regulated secretory pathway.The RGD motif and the C-terminal segment of proprotein convertase 1 are critical for its cellular trafficking but not for its intracellular binding to integrin alpha5beta1.The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro.Mutations of the PC2 substrate binding pocket alter enzyme specificity.A predicted alpha -helix mediates targeting of the proprotein convertase PC1 to the regulated secretory pathway.The protease-associated domain and C-terminal extension are required for zymogen processing, sorting within the secretory pathway, and activity of tomato subtilase 3 (SlSBT3).Molecular characterization of the cDNA and localization of the mRNA encoding the prohormone convertase PC5-A in the European green frog.Structural organization of precursors of thermolysin-like proteinases.Basic mechanisms of secretion: sorting into the regulated secretory pathway
P2860
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P2860
The integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
The integrity of the RRGDL seq ...... for its cellular trafficking.
@en
The integrity of the RRGDL seq ...... for its cellular trafficking.
@nl
type
label
The integrity of the RRGDL seq ...... for its cellular trafficking.
@en
The integrity of the RRGDL seq ...... for its cellular trafficking.
@nl
prefLabel
The integrity of the RRGDL seq ...... for its cellular trafficking.
@en
The integrity of the RRGDL seq ...... for its cellular trafficking.
@nl
P2093
P2860
P356
P1433
P1476
The integrity of the RRGDL seq ...... for its cellular trafficking.
@en
P2093
P2860
P304
P356
10.1042/BJ3260737
P407
P478
326 ( Pt 3)
P577
1997-09-01T00:00:00Z