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Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation.Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new set of data for predictive in silico ADME models.Enantioselective HPLC-UV method for determination of eslicarbazepine acetate (BIA 2-093) and its metabolites in human plasma.Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma.A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain.Chiral chromatographic resolution of antiepileptic drugs and their metabolites: a challenge from the optimization to the application.Development of a liquid chromatography assay for the determination of opicapone and BIA 9-1079 in rat matrices.Bioanalytical chromatographic methods for the determination of catechol-O-methyltransferase inhibitors in rodents and human samples: a review.Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: a review.Liquid chromatographic methods for the quantification of catecholamines and their metabolites in several biological samples--a review.A critical review of microextraction by packed sorbent as a sample preparation approach in drug bioanalysis.Venlafaxine pharmacokinetics focused on drug metabolism and potential biomarkers.Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules.Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review.Clinical drug-drug interactions: focus on venlafaxine.Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays.Early preclinical evaluation of dihydropyrimidin(thi)ones as potential anticonvulsant drug candidates.Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells.Pharmacist Interventions in the Management of Type 2 Diabetes Mellitus: A Systematic Review of Randomized Controlled Trials.HepaRG cell line as an in vitro model for screening drug-drug interactions mediated by metabolic induction: amiodarone used as a model substance.Gastrodia elata and epilepsy: Rationale and therapeutic potential.Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders.Can the CEIBA Cocktail Designed for Human Cytochrome P450 Enzymes be Used in the Rat for Drug Interaction Studies?Development and application of an ex vivo fosphenytoin nasal bioconversion/permeability evaluation method.Intranasal Delivery of Topically-Acting Levofloxacin to Rats: a Proof-of-Concept Pharmacokinetic Study.Intranasal delivery of ciprofloxacin to rats: A topical approach using a thermoreversible in situ gel.Herb-Drug Interaction of Paullinia cupana (Guarana) Seed Extract on the Pharmacokinetics of Amiodarone in Rats.Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: no interference with carbamazepine and its metabolites.Binding of licarbazepine enantiomers to mouse and human plasma proteins.Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma.Usefulness of factor II and factor X as therapeutic markers in patients under chronic warfarin therapy.First liquid chromatographic method for the simultaneous determination of amiodarone and desethylamiodarone in human plasma using microextraction by packed sorbent (MEPS) as sample preparation procedure.A rapid HPLC method for the simultaneous determination of amiodarone and its major metabolite in rat plasma and tissues: a useful tool for pharmacokinetic studies.Disposition of eslicarbazepine acetate in the mouse after oral administration.Stereoselective disposition of S- and R-licarbazepine in mice.Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors.Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.Steroidal oximes: useful compounds with antitumor activities.
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P50
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հետազոտող
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Gilberto Alves
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Gilberto Alves
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Gilberto Alves
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Gilberto Alves
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Gilberto Alves
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Gilberto Alves
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Gilberto Alves
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Gilberto Alves
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Gilberto Alves
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Gilberto Alves
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Gilberto Alves
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Gilberto Alves
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Gilberto Alves
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Gilberto Alves
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Gilberto Alves
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55663631700
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0000-0002-4213-0714