Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells. - Wikidata - awgldk - TriplyDB

Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells.

Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells.

http://www.wikidata.org/entity/Q43011656

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Role of endoplasmic reticulum stress in drug-induced toxicity The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity Efavirenz and the CNS: what we already know and questions that need to be answered Efavirenz promotes β-secretase expression and increased Aβ1-40,42 via oxidative stress and reduced microglial phagocytosis: implications for HIV associated neurocognitive disorders (HAND).Antiretroviral therapy-induced mitochondrial toxicity: potential mechanisms beyond polymerase-γ inhibition.Enhanced oxidative stress and increased mitochondrial mass during efavirenz-induced apoptosis in human hepatic cells.Mitochondrial bioenergetic alterations in mouse neuroblastoma cells infected with Sindbis virus: implications to viral replication and neuronal death.Efavirenz induces neuronal autophagy and mitochondrial alterations.Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I.Lipodystrophy: pathophysiology and advances in treatment Mitochondrial (dys)function - a factor underlying the variability of efavirenz-induced hepatotoxicity?Dysregulation of Endoplasmic Reticulum Stress and Autophagic Responses by the Antiretroviral Drug Efavirenz.Changes in fat mitochondrial DNA and function in subjects randomized to abacavir-lamivudine or tenofovir DF-emtricitabine with atazanavir-ritonavir or efavirenz: AIDS Clinical Trials Group study A5224s, substudy of A5202.Risk Factors for Incident Diabetes in a Cohort Taking First-Line Nonnucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy.Role of mitochondria in HIV infection and associated metabolic disorders: focus on nonalcoholic fatty liver disease and lipodystrophy syndrome.High frequency of mitochondrial DNA mutations in HIV-infected treatment-experienced individuals.Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity Disease drivers of aging.Management of fat accumulation in patients with HIV infection.Central role of mitochondria in drug-induced liver injury.Neuronal toxicity of efavirenz: a systematic review.Exploring the pathophysiology behind the more common genetic and acquired lipodystrophies.Mechanisms of isoniazid-induced idiosyncratic liver injury: emerging role of mitochondrial stress.In vitro and Ex vivo Neurotoxic Effects of Efavirenz are Greater than Those of Other Common Antiretrovirals.The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction.Involvement of nitric oxide in the mitochondrial action of efavirenz: a differential effect on neurons and glial cells.Lack of mitochondrial toxicity of darunavir, raltegravir and rilpivirine in neurons and hepatocytes: a comparison with efavirenz.Changes in liver steatosis evaluated by transient elastography with the controlled attenuation parameter in HIV-infected patients.Central nervous system-penetrating antiretrovirals impair energetic reserve in striatal nerve terminals.Nevirapine induced mitochondrial dysfunction in HepG2 cells.Effect of the Anti-retroviral Drugs Efavirenz, Tenofovir and Emtricitabine on Endothelial Cell Function: Role of PARP.Depolarization of mitochondrial membrane potential is the initial event in non-nucleoside reverse transcriptase inhibitor efavirenz induced cytotoxicity.Improvement of lipoatrophy by switching from efavirenz to lopinavir/ritonavir.Impaired sperm motility in HIV-infected men: an unexpected adverse effect of efavirenz?Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes.The role of pparγ and autophagy in ros production, lipid droplets biogenesis and its involvement with colorectal cancer cells modulation.Severe efavirenz-induced vacuolar axonopathy complicated by fatal aspiration pneumonia.PharmGKB summary: isoniazid pathway, pharmacokinetics.Pharmacotoxicology of monocyte-macrophage nanoformulated antiretroviral drug uptake and carriage 8-Hydroxy-efavirenz, the primary metabolite of the antiretroviral drug Efavirenz, stimulates the glycolytic flux in cultured rat astrocytes.

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Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells.

http://www.wikidata.org/entity/Q43011656

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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name

Inhibition of mitochondrial fu ...... ipid content in hepatic cells.

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Inhibition of mitochondrial fu ...... ipid content in hepatic cells.

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type

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Inhibition of mitochondrial fu ...... ipid content in hepatic cells.

@en

Inhibition of mitochondrial fu ...... ipid content in hepatic cells.

@nl

prefLabel

Inhibition of mitochondrial fu ...... ipid content in hepatic cells.

@en

Inhibition of mitochondrial fu ...... ipid content in hepatic cells.

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Inhibition of mitochondrial fu ...... ipid content in hepatic cells.

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Ana Blas-García

http://www.w3.org/2001/XMLSchema#string

Daniel Monleón

http://www.w3.org/2001/XMLSchema#string

Jose M Morales

http://www.w3.org/2001/XMLSchema#string

Juan V Esplugues

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P2860

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients.

Hepatotoxicity due to mitochondrial dysfunction.

Inhibition of mitochondrial respiration by endogenous nitric oxide: a critical step in Fas signaling.

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using plasma drug level monitoring.

Interpatient variability in the pharmacokinetics of the HIV non-nucleoside reverse transcriptase inhibitor efavirenz: the effect of gender, race, and CYP2B6 polymorphism

Nile red: a selective fluorescent stain for intracellular lipid droplets.

Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.

Metabonomics in pharmaceutical R&D.

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115-125

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10.1002/HEP.23647

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1

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52

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Nadezda Apostolova

Víctor M Víctor

Daniel Ballesteros

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2010-07-01T00:00:00Z

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44688940

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20564379

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