Synthesis of stable isotope labeled analogs of the anti-hepatitis C virus nucleotide prodrugs PSI-7977 and PSI-352938.

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Synthesis and biological evaluation of 12-N-p-chlorobenzyl sophoridinol derivatives as a novel family of anticancer agents.

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Synthesis of stable isotope labeled analogs of the anti-hepatitis C virus nucleotide prodrugs PSI-7977 and PSI-352938.

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2011 nî lūn-bûn

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年學術文章

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name

Synthesis of stable isotope la ...... drugs PSI-7977 and PSI-352938.

@en

Synthesis of stable isotope la ...... drugs PSI-7977 and PSI-352938.

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type

Item

label

Synthesis of stable isotope la ...... drugs PSI-7977 and PSI-352938.

@en

Synthesis of stable isotope la ...... drugs PSI-7977 and PSI-352938.

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Synthesis of stable isotope la ...... drugs PSI-7977 and PSI-352938.

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Synthesis of stable isotope la ...... drugs PSI-7977 and PSI-352938.

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Synthesis of stable isotope la ...... drugs PSI-7977 and PSI-352938.

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Bruce S Ross

http://www.w3.org/2001/XMLSchema#string

Byoung-Kwon Chun

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Christine L Espiritu

http://www.w3.org/2001/XMLSchema#string

Donghui Bao

http://www.w3.org/2001/XMLSchema#string

Hai-Ren Zhang

http://www.w3.org/2001/XMLSchema#string

Holly M Micolochick Steuer

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Jinfa Du

http://www.w3.org/2001/XMLSchema#string

Meg Keilman

http://www.w3.org/2001/XMLSchema#string

Michael J Sofia

http://www.w3.org/2001/XMLSchema#string

Phillip A Furman

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P2860

PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication

The synthesis of deuterionucleosides.

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.

Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine.

2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.

One-pot two-step enzymatic coupling of pyrimidine bases to 2-deoxy-D-ribose-5-phosphate. A new strategy in the synthesis of stable isotope labeled deoxynucleosides.

Use of 13C as an indirect tag in 15N specifically labeled nucleosides. Syntheses of [8-13C-1,7,NH2-15N3]adenosine, -guanosine, and their deoxy analogues.

Synthesis of 2'-C-beta-methyl-2'-deoxyguanosine.

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886-896

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scholarly article

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10.1080/15257770.2011.614308

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2011-11-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

22060553

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P921

stable isotope

Synthesis of stable isotope labeled analogs of the anti-hepatitis C virus nucleotide prodrugs PSI-7977 and PSI-352938.

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P2860

P2860

Synthesis of stable isotope labeled analogs of the anti-hepatitis C virus nucleotide prodrugs PSI-7977 and PSI-352938.

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