about
Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine MonophosphateCETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP poolN-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitorsInhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosisSolution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricusScreening for Target Engagement using the Cellular Thermal Shift Assay - CETSAOct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced foldingStructure-based screening as applied to human FABP4: a highly efficient alternative to HTS for hit generation.The cellular thermal shift assay for evaluating drug target interactions in cells.Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates.Binding to and Inhibition of Insulin-Regulated Aminopeptidase by Macrocyclic Disulfides Enhances Spine Density.Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening.Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures.In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis.Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1Thermodynamics of sequence-specific protein-DNA interactions.Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.Early Perspective.Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery.dUTPase inhibition augments replication defects of 5-Fluorouracil.Immunomodulatory activity of commonly used drugs on Fc-receptor-mediated human natural killer cell activation.A novel assay of cellular stearoyl-CoA desaturase activity of primary rat hepatocytes by HPLC.Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides.Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target.Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors.Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis.Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1.CETSA: a target engagement assay with potential to transform drug discovery.In Situ Target Engagement Studies in Adherent Cells.Oligomerization of the chromatin-structuring protein H-NS.Identification of inhibitors of Tartrate-resistant acid phosphatase (TRAP/ACP5) activity by small-molecule screening.Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems.Sequence-Specific DNA Binding by the Glucocorticoid Receptor DNA-Binding Domain Is Linked to a Salt-Dependent Histidine Protonation†Thermodynamic characterization of non-sequence-specific DNA-binding by the Sso7d protein from Sulfolobus solfataricusStructure and Dynamics of the Glucocorticoid Receptor DNA-Binding Domain: Comparison of Wild Type and a Mutant with Altered Specificity†
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Thomas Lundbäck
@ast
Thomas Lundbäck
@en
Thomas Lundbäck
@es
Thomas Lundbäck
@nl
Thomas Lundbäck
@sl
type
label
Thomas Lundbäck
@ast
Thomas Lundbäck
@en
Thomas Lundbäck
@es
Thomas Lundbäck
@nl
Thomas Lundbäck
@sl
prefLabel
Thomas Lundbäck
@ast
Thomas Lundbäck
@en
Thomas Lundbäck
@es
Thomas Lundbäck
@nl
Thomas Lundbäck
@sl
P106
P21
P31
P496
0000-0002-8145-7808