Functional genomics identifies a requirement of pre-mRNA splicing factors for sister chromatid cohesion.
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Splicing together sister chromatids.SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex.The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.Intronic cleavage and polyadenylation regulates gene expression during DNA damage response through U1 snRNAThe molecular pathogenesis of the myelodysplastic syndromes.The interplay between DNA damage response and RNA processing: the unexpected role of splicing factors as gatekeepers of genome stability.RNA Processing and Genome Stability: Cause and Consequence.Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway.Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion.The cohesion stabilizer sororin favors DNA repair and chromosome segregation during mouse oocyte meiosis.Profiling DNA damage response following mitotic perturbations.A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment.Graded requirement for the spliceosome in cell cycle progressionPARP inhibition causes premature loss of cohesion in cancer cells.The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells.The localization of pre mRNA splicing factor PRPF38B is a novel prognostic biomarker that may predict survival benefit of trastuzumab in patients with breast cancer overexpressing HER2.Large-Scale Analysis of CRISPR/Cas9 Cell-Cycle Knockouts Reveals the Diversity of p53-Dependent Responses to Cell-Cycle Defects.Therapy-induced stress response is associated with downregulation of pre-mRNA splicing in cancer cells.
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P2860
Functional genomics identifies a requirement of pre-mRNA splicing factors for sister chromatid cohesion.
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name
Functional genomics identifies ...... for sister chromatid cohesion.
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Functional genomics identifies ...... for sister chromatid cohesion.
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Functional genomics identifies ...... for sister chromatid cohesion.
@en
Functional genomics identifies ...... for sister chromatid cohesion.
@nl
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Functional genomics identifies ...... for sister chromatid cohesion.
@en
Functional genomics identifies ...... for sister chromatid cohesion.
@nl
P2093
P2860
P356
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Functional genomics identifies ...... for sister chromatid cohesion.
@en
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María Dolores Vázquez-Novelle
Sergey Lekomtsev
Sriramkumar Sundaramoorthy
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P304
P356
10.15252/EMBJ.201488244
P407
P577
2014-09-25T00:00:00Z