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LC-MS/MS method for the determination of haemanthamine in rat plasma, bile and urine and its application to a pilot pharmacokinetic study.Effective Method of Purification of Betulin from Birch Bark: The Importance of Its Purity for Scientific and Medicinal UseThe cytotoxic effect of α-tomatine in MCF-7 human adenocarcinoma breast cancer cells depends on its interaction with cholesterol in incubation media and does not involve apoptosis induction.Comparative cytotoxicity of chelidonine and homochelidonine, the dimethoxy analogues isolated from Chelidonium majus L. (Papaveraceae), against human leukemic and lung carcinoma cells.Synthesis, structural characterization, docking, lipophilicity and cytotoxicity of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-alkyl carbamates, novel acetylcholinesterase and butyrylcholinesterase pseudo-irreversible inhibitors.Study of antitumor effect of selected vanadium and molybdenum organometallic complexes in human leukemic T-cells.Ionizing radiation increases primary cilia incidence and induces multiciliation in C2C12 myoblasts.Changes in the response of MCF-7 cells to ionizing radiation after the combination of ATM and DNA-PK inhibition.The effect of Amaryllidaceae alkaloids haemanthamine and haemanthidine on cell cycle progression and apoptosis in p53-negative human leukemic Jurkat cells.Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis.Lymphocyte subsets and their H2AX phosphorylation in response to in vivo irradiation in rats.Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity.Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells.The response of human ectomesenchymal dental pulp stem cells to cisplatin treatment.Anticancer potential of Amaryllidaceae alkaloids evaluated by screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice.Specific inhibition of Wee1 kinase and Rad51 recombinase: a strategy to enhance the sensitivity of leukemic T-cells to ionizing radiation-induced DNA double-strand breaks.Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells.Boldine Inhibits Mouse Mammary Carcinoma In Vivo and Human MCF-7 Breast Cancer Cells In Vitro.In-vitro and in-vivo evaluation of the anticancer activity of diruthenium-2, a new trithiolato arene ruthenium complex [(η6-p-MeC6H4Pri)2Ru2(μ-S-p-C6H4OH)3]Cl.The effect of ATM kinase inhibition on the initial response of human dental pulp and periodontal ligament mesenchymal stem cells to ionizing radiation.Gamma radiation induces senescence in human adult mesenchymal stem cells from bone marrow and periodontal ligaments.Bersavine: A Novel Bisbenzylisoquinoline Alkaloidwith Cytotoxic, Antiproliferative and Apoptosis-Inducing Effects on Human Leukemic CellsEnhanced cytotoxicity of indenyl molybdenum(ii) compounds bearing a thiophene functionChemical and Biological Aspects of Montanine-Type Alkaloids Isolated from Plants of the Amaryllidaceae Family
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description
hulumtues
@sq
lékařský chemik a biochemik (Ú ...... rzita Karlova, Hradec Králové)
@cs
onderzoeker
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researcher
@en
ricercatore
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հետազոտող
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name
Radim Havelek
@ast
Radim Havelek
@cs
Radim Havelek
@en
Radim Havelek
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Radim Havelek
@nl
Radim Havelek
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type
label
Radim Havelek
@ast
Radim Havelek
@cs
Radim Havelek
@en
Radim Havelek
@es
Radim Havelek
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Radim Havelek
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prefLabel
Radim Havelek
@ast
Radim Havelek
@cs
Radim Havelek
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Radim Havelek
@es
Radim Havelek
@nl
Radim Havelek
@sl
P106
P1053
S-5723-2016
P21
P214
14154921373563592781
P31
P3829
P496
0000-0003-0528-1334