Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains. - Wikidata - awgldk - TriplyDB

Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains.

Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains.

http://www.wikidata.org/entity/Q43126193

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Landmarks in insulin research How insulin engages its primary binding site on the insulin receptor Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS Design of an Insulin Analog with Enhanced Receptor Binding Selectivity: RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONS Crystal Structure of a"Nonfoldable"Insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY Solution Structure of Proinsulin: CONNECTING DOMAIN FLEXIBILITY AND PROHORMONE PROCESSING Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues Non-equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface Structural Integrity of the B24 Site in Human Insulin Is Important for Hormone Functionality Insight into the Structural and Biological Relevance of the T/R Transition of the N-Terminus of the B-Chain in Human Insulin Protective hinge in insulin opens to enable its receptor engagement Engineering of insulin receptor isoform-selective insulin analogues Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.Contribution of TyrB26 to the Function and Stability of Insulin: STRUCTURE-ACTIVITY RELATIONSHIPS AT A CONSERVED HORMONE-RECEPTOR INTERFACE.An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic design Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.Flexibility in the insulin receptor ectodomain enables docking of insulin in crystallographic conformation observed in a hormone-bound microreceptor.Proinsulin and the genetics of diabetes mellitus α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase.Insulin: a small protein with a long journey.The insulin receptor changes conformation in unforeseen ways on ligand binding: sharpening the picture of insulin receptor activation.Theoretical and computational studies of peptides and receptors of the insulin family.Computational study of the activity, dynamics, energetics and conformations of insulin analogues using molecular dynamics simulations: Application to hyperinsulinemia and the critical residue B26.A docking study of insulin with LI-CR-L2 ecto domain of insulin receptor: an easy way for preliminary screening of novel anti-diabetic peptides Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex.Analysis of protein ligand-receptor binding by photoaffinity cross-linking.Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding.Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element.

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P2860

Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains.

http://www.wikidata.org/entity/Q43126193

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

@zh-cn

2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

@zh-hant

name

Decoding the cryptic active co ...... arm between receptor domains.

@en

Decoding the cryptic active co ...... arm between receptor domains.

@nl

type

label

Decoding the cryptic active co ...... arm between receptor domains.

@en

Decoding the cryptic active co ...... arm between receptor domains.

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prefLabel

Decoding the cryptic active co ...... arm between receptor domains.

@en

Decoding the cryptic active co ...... arm between receptor domains.

@nl

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Journal of Biological Chemistry

P1476

Decoding the cryptic active co ...... arm between receptor domains.

@en

P2093

Bin Xu

http://www.w3.org/2001/XMLSchema#string

Jonathan Whittaker

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Kun Huang

http://www.w3.org/2001/XMLSchema#string

Michael A Weiss

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Panayotis G Katsoyannis

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Run-Ying Wang

http://www.w3.org/2001/XMLSchema#string

Satoe Nakagawa

http://www.w3.org/2001/XMLSchema#string

Shi-Quan Hu

http://www.w3.org/2001/XMLSchema#string

Shuhua Wang

http://www.w3.org/2001/XMLSchema#string

Ying-Chi Chu

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P2860

The solution structure of a superpotent b-chain-shortened single-replacement insulin analogue

Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue

Structure of insulin in 4-zinc insulin

The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice

X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue.

Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS

Receptor binding redefined by a structural switch in a mutant human insulin

The structure of 2Zn pig insulin crystals at 1.5 A resolution

Structure of a protein in a kinetic trap

Solution structure of an engineered insulin monomer at neutral pH

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