about
Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activityInhibition of both focal adhesion kinase and fibroblast growth factor receptor 2 pathways induces anti-tumor and anti-angiogenic activitiesA RasGAP SH3 peptide aptamer inhibits RasGAP-Aurora interaction and induces caspase-independent tumor cell deathp120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling.Current concepts regarding the HTLV-1 receptor complex.Depletion of the novel protein PHACTR-1 from human endothelial cells abolishes tube formation and induces cell death receptor apoptosis.Neuropilin-1 regulates a new VEGF-induced gene, Phactr-1, which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells.Common variable immunodeficiency is associated with defective functions of dendritic cells.Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model.Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursorsControl of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions.Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence.New therapeutic approaches for adult T-cell leukaemia.Retinoids regulate survival and antigen presentation by immature dendritic cells.Short interfering RNA (siRNA), a novel therapeutic tool acting on angiogenesis.Recent advances in adult T-cell leukemia therapy: focus on a new anti-transferrin receptor monoclonal antibody.Deregulation of microRNA involved in hematopoiesis and the immune response in HTLV-I adult T-cell leukemia.Neuropilins, semaphorins, and their role in thymocyte development.Natural antibodies sustain differentiation and maturation of human dendritic cells.The telomere/telomerase system in autoimmune and systemic immune-mediated diseases.Synthesis and structure-activity relationship of non-peptidic antagonists of neuropilin-1 receptor.Immunological alterations and associated diseases in mandrills (Mandrillus sphinx) naturally co-infected with SIV and STLV.RasV12 induces Survivin/AuroraB pathway conferring tumor cell apoptosis resistance.T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells.Prevention of mantle lymphoma tumor establishment by routing transferrin receptor toward lysosomal compartments.Efficacy and mechanism of action of the proteasome inhibitor PS-341 in T-cell lymphomas and HTLV-I associated adult T-cell leukemia/lymphoma.DOR-1, A novel CD10+ stromal cell line derived from progressive Langerhans cell histiocytosis of bone.Disruption of phactr-1 pathway triggers pro-inflammatory and pro-atherogenic factors: New insights in atherosclerosis development.Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry.Free HTLV-1 induces TLR7-dependent innate immune response and TRAIL relocalization in killer plasmacytoid dendritic cells.Human Muscle Progenitor Cells Displayed Immunosuppressive Effect through Galectin-1 and Semaphorin-3AEAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I-associated adult T-cell leukemia/lymphoma.Galectin-1 and semaphorin-3A are two soluble factors conferring T-cell immunosuppression to bone marrow mesenchymal stem cell.Toll-like receptor control of glucocorticoid-induced apoptosis in human plasmacytoid predendritic cells (pDCs).Arsenic/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1-infected leukemic cells.Apoptosis-induced proteinase 3 membrane expression is independent from degranulation.No association between Langerhans cell histiocytosis and human herpes virus 8.Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum.[Current concepts and treatment advances in systemic mastocytosis].NRPa-308, a new neuropilin-1 antagonist, exerts in vitro anti-angiogenic and anti-proliferative effects and in vivo anti-cancer effects in a mouse xenograft model.
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description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
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Yves Lepelletier
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Yves Lepelletier
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Yves Lepelletier
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Yves Lepelletier
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Yves Lepelletier
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Yves Lepelletier
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Yves Lepelletier
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Yves Lepelletier
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Yves Lepelletier
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Yves Lepelletier
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Yves Lepelletier
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Yves Lepelletier
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Yves Lepelletier
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Yves Lepelletier
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Yves Lepelletier
@sl
P106
P21
P31
P496
0000-0001-7746-5170