about
Getting specificity from simplicity in putative proteins from the prebiotic EarthStructure of the C-terminal domain of transcription factor IIB from Trypanosoma bruceiThe TDP-43 N-terminal domain structure at high resolutionCommon features at the start of the neurodegeneration cascadeGlycosylation and specific deamidation of ribonuclease B affect the formation of three-dimensional domain-swapped oligomers.Three-dimensional domain-swapped oligomers of ribonuclease A: identification of a fifth tetramer, pentamers and hexamers, and detection of trace heptameric, octameric and nonameric species.Pressure-jump-induced kinetics reveals a hydration dependent folding/unfolding mechanism of ribonuclease AHolo- and apo-cystalysin from Treponema denticola: two different conformations.Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A.NMR structural determinants of eosinophil cationic protein binding to membrane and heparin mimeticsCharacterization of the structure and self-recognition of the human centrosomal protein NA14: implications for stability and function.NMR spectroscopy reveals that RNase A is chiefly denatured in 40% acetic acid: implications for oligomer formation by 3D domain swapping.Double domain swapping in bovine seminal RNase: formation of distinct N- and C-swapped tetramers and multimers with increasing biological activitiesTowards tricking a pathogen's protease into fighting infection: the 3D structure of a stable circularly permuted onconase variant cleavedby HIV-1 proteaseCombining Classical MD and QM calculations to elucidate complex system nucleation: a twisted, three-stranded, parallel β-sheet seeds amyloid fibril conception.Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation.The structural determinants that lead to the formation of particular oligomeric structures in the pancreatic-type ribonuclease family.Structural and functional relationships of natural and artificial dimeric bovine ribonucleases: new scaffolds for potential antitumor drugs."Structural characterization of the minimal segment of TDP-43 competent for aggregation".Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.NMR spectroscopy reveals a preferred conformation with a defined hydrophobic cluster for polyglutamine binding peptide 1.Some biological actions of PEG-conjugated RNase A oligomers.Interaction of PiB-derivative metal complexes with beta-amyloid peptides: selective recognition of the aggregated forms.Folding pathway of the pyridoxal 5'-phosphate C-S lyase MalY from Escherichia coli.Destabilizing mutations alter the hydrogen exchange mechanism in ribonuclease A.Purification of recombinant ribonuclease T1 expressed in Escherichia coli.Interactions crucial for three-dimensional domain swapping in the HP-RNase variant PM8.Different protein sequences can give rise to highly similar folds through different stabilizing interactions.Putative one-pot prebiotic polypeptides with ribonucleolytic activity.Charge-charge interactions are key determinants of the pK values of ionizable groups in ribonuclease Sa (pI=3.5) and a basic variant (pI=10.2).Tautomeric state of alpha-sarcin histidines. Ndelta tautomers are a common feature in the active site of extracellular microbial ribonucleases.pH dependence of the urea and guanidine hydrochloride denaturation of ribonuclease A and ribonuclease T1.Alzheimer's Abeta40 studied by NMR at low pH reveals that sodium 4,4-dimethyl-4-silapentane-1-sulfonate (DSS) binds and promotes beta-ball oligomerization.Gemini surfactants affect the structure, stability, and activity of ribonuclease Sa.Carbodiimide EDC induces cross-links that stabilize RNase A C-dimer against dissociation: EDC adducts can affect protein net charge, conformation, and activity.Structural similarity of DNA-binding domains of bacteriophage repressors and the globin core.Kinetic analysis provides insight into the mechanism of ribonuclease A oligomer formation.Charge substitution shows that repulsive electrostatic interactions impede the oligomerization of Alzheimer amyloid peptides.Characterization of the unfolding pathway of hen egg white lysozyme.Structure of a simplified β-hairpin and its ATP complex.
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
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հետազոտող
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name
Douglas V Laurents
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Douglas V Laurents
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Douglas V Laurents
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Douglas V Laurents
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Douglas V Laurents
@sl
type
label
Douglas V Laurents
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Douglas V Laurents
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Douglas V Laurents
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Douglas V Laurents
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Douglas V Laurents
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prefLabel
Douglas V Laurents
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Douglas V Laurents
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Douglas V Laurents
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Douglas V Laurents
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Douglas V Laurents
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P1053
E-7527-2015
P106
P21
P31
P3829
P496
0000-0002-4187-165X