A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. - Wikidata - awgldk - TriplyDB

A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal.

A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal.

http://www.wikidata.org/entity/Q43148740

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Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning Genomic screening with RNAi: results and challenges Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity The Ccr4-Not complex is a key regulator of eukaryotic gene expression TRIM28 as a novel transcriptional elongation factor KAPtain in charge of multiple missions: Emerging roles of KAP1 High-throughput screening to enhance oncolytic virus immunotherapy SMC complexes link gene expression and genome architecture The transcriptional regulation of pluripotency Synthetic lethal screens as a means to understand and treat MYC-driven cancers KAP1 regulates gene networks controlling T-cell development and responsiveness.Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export CRISPR-Mediated Epigenome Editing The role of TREX in gene expression and disease An expanded Oct4 interaction network: implications for stem cell biology, development, and disease KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming Regulation of Mouse Retroelement MuERV-L/MERVL Expression by REX1 and Epigenetic Control of Stem Cell Potency LIF-dependent signaling: new pieces in the Lego The Zfx gene is expressed in human gliomas and is important in the proliferation and apoptosis of the human malignant glioma cell line U251 Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2 lincRNAs act in the circuitry controlling pluripotency and differentiation Control of the embryonic stem cell state Master transcription factors and mediator establish super-enhancers at key cell identity genes Organic small hairpin RNAs (OshR): a do-it-yourself platform for transgene-based gene silencing.A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.ZFX controls the self-renewal of human embryonic stem cells A direct phenotypic comparison of siRNA pools and multiple individual duplexes in a functional assay.A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4.Stem cell characteristics in glioblastoma are maintained by the ecto-nucleotidase E-NPP1.KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genes Descriptive no more: the dawn of high-throughput microscopy.The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype.Cnot3 enhances human embryonic cardiomyocyte proliferation by promoting cell cycle inhibitor mRNA degradation.NANOG reporter cell lines generated by gene targeting in human embryonic stem cells.

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P2860

A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal.

http://www.wikidata.org/entity/Q43148740

description

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2009年の論文

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name

A genome-wide RNAi screen iden ...... ule required for self-renewal.

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A genome-wide RNAi screen iden ...... ule required for self-renewal.

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A genome-wide RNAi screen iden ...... ule required for self-renewal.

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A genome-wide RNAi screen iden ...... ule required for self-renewal.

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A genome-wide RNAi screen iden ...... ule required for self-renewal.

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Guang Hu

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Jonghwan Kim

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Qikai Xu

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Stephen J Elledge

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Stuart H Orkin

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Yumei Leng

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P2860

KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.

Embryonic stem cell differentiation: emergence of a new era in biology and medicine

Core transcriptional regulatory circuitry in human embryonic stem cells

Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

A protein interaction network for pluripotency of embryonic stem cells

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