TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice.
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International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel familyLife and death of sensory hair cells expressing constitutively active TRPML3The role of TRPMLs in endolysosomal trafficking and functionHCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small moleculesThe physiology of mechanoelectrical transduction channels in hearing.A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.Linking genes underlying deafness to hair-bundle development and function.Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in miceFast adaptation and Ca2+ sensitivity of the mechanotransducer require myosin-XVa in inner but not outer cochlear hair cells.TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells.Expression and vesicular localization of mouse Trpml3 in stria vascularis, hair cells, and vomeronasal and olfactory receptor neuronsSmall molecule activators of TRPML3Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis.Constitutive activity of the human TRPML2 channel induces cell degenerationMucolipins: Intracellular TRPML1-3 channelsThe Ca(2+) channel TRPML3 regulates membrane trafficking and autophagyMucolipin-3 regulates luminal calcium, acidification, and membrane fusion in the endosomal pathway.Constitutive activity of TRP channels methods for measuring the activity and its outcome.TRPML: transporters of metals in lysosomes essential for cell survival?Permeation properties of the hair cell mechanotransducer channel provide insight into its molecular structureHair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.TRPMLs: in sickness and in health.Defining features of the hair cell mechanoelectrical transducer channelTRP channels.The how and why of identifying the hair cell mechano-electrical transduction channelOpening the TRPML gates.Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells.Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells?
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P2860
TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice.
description
2008 nî lūn-bûn
@nan
2008年の論文
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2008年学术文章
@wuu
2008年学术文章
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2008年学术文章
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2008年学术文章
@zh-hans
2008年学术文章
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2008年学术文章
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2008年學術文章
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2008年學術文章
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name
TRPML3 mutations cause impaire ...... ells of varitint-waddler mice.
@en
TRPML3 mutations cause impaire ...... ells of varitint-waddler mice.
@nl
type
label
TRPML3 mutations cause impaire ...... ells of varitint-waddler mice.
@en
TRPML3 mutations cause impaire ...... ells of varitint-waddler mice.
@nl
prefLabel
TRPML3 mutations cause impaire ...... ells of varitint-waddler mice.
@en
TRPML3 mutations cause impaire ...... ells of varitint-waddler mice.
@nl
P2093
P2860
P1476
TRPML3 mutations cause impaire ...... ells of varitint-waddler mice.
@en
P2093
Alexander F J van Aken
Corné J Kros
Guy P Richardson
Jane E Bryant
Konrad Noben-Trauth
Margaret Atiba-Davies
Richard J Goodyear
Walter Marcotti
P2860
P304
P356
10.1113/JPHYSIOL.2008.156992
P407
P577
2008-09-18T00:00:00Z