Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
about
Quinoxaline 1,4-di-N-Oxides: Biological Activities and Mechanisms of ActionsSystematic and Molecular Basis of the Antibacterial Action of Quinoxaline 1,4-Di-N-Oxides against Escherichia coliIsotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxideABC transporters in CSCs membranes as a novel target for treating tumor relapse.Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumorsMechanisms of Antibacterial Action of Quinoxaline 1,4-di-N-oxides against Clostridium perfringens and Brachyspira hyodysenteriae.Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia.Design of optimized hypoxia-activated prodrugs using pharmacokinetic/pharmacodynamic modeling.Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.
P2860
Q26752388-3FF873F4-400A-4BFA-9667-2F2DA47FA984Q28547408-ACAB7250-8A2C-46B7-AAEE-14AA92A095F9Q33575435-A70307AD-75BE-46C6-A813-1915C37E69E6Q33879326-4157DF86-E2E6-4729-A20D-D3575AD479D7Q34061361-434FCA3F-4D2E-4C05-B2CF-5B506330FE8FQ36079855-C37C2999-4A51-4E29-AF6B-25B5D2DDEB13Q37488507-3AC9CD1A-64A1-491B-ADDF-5EDCC1A72DB4Q38120850-25731616-A628-46BC-94E0-850C5E8BFCD2Q38177279-02B8B0E6-76DA-47BD-9A8D-7B26F83BDB52Q46905097-ED8A07CB-31C1-4EFA-91F1-EE701031D3AE
P2860
Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Characterization of radicals f ...... ne 1,4-dioxide (tirapazamine).
@en
Characterization of radicals f ...... ne 1,4-dioxide (tirapazamine).
@nl
type
label
Characterization of radicals f ...... ne 1,4-dioxide (tirapazamine).
@en
Characterization of radicals f ...... ne 1,4-dioxide (tirapazamine).
@nl
prefLabel
Characterization of radicals f ...... ne 1,4-dioxide (tirapazamine).
@en
Characterization of radicals f ...... ne 1,4-dioxide (tirapazamine).
@nl
P2093
P356
P1476
Characterization of radicals f ...... ne 1,4-dioxide (tirapazamine).
@en
P2093
Andrej Maroz
Robert F Anderson
Sujata S Shinde
William A Denny
P304
P356
10.1021/JA908689F
P407
P577
2010-03-01T00:00:00Z