about
Complex formation between S100B protein and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is calcium-dependent and inhibits extracellular signal-regulated kinase (ERK)-mediated phosphorylation of RSKMetastatic breast tumors express increased tau, which promotes microtentacle formation and the reattachment of detached breast tumor cellsα-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration.A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces apoptosis in PTEN and PIK3CA mutant human cancer cellsTwo functional S100A4 monomers are necessary for regulating nonmuscle myosin-IIA and HCT116 cell invasionLoss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis.Tamoxifen-stimulated growth of breast cancer due to p21 lossQuantitative imaging of mitochondrial and cytosolic free zinc levels in an in vitro model of ischemia/reperfusion.The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence.Pharmacologic regulation of AMPK in breast cancer affects cytoskeletal properties involved with microtentacle formation and re-attachmentLoss of PTEN induces microtentacles through PI3K-independent activation of cofilinDeletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cellsParthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibition.Curcumin targets breast cancer stem-like cells with microtentacles that persist in mammospheres and promote reattachment.Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells.Persistent mismatch repair deficiency following targeted correction of hMLH1.Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells.Gauging the Impact of Cancer Treatment Modalities on Circulating Tumor Cells (CTCs)
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description
researcher
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wetenschapper
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հետազոտող
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name
Michele Vitolo
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Michele Vitolo
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Michele Vitolo
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Michele Vitolo
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Michele Vitolo
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Michele Vitolo
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Michele Vitolo
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Michele Vitolo
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Michele Vitolo
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Michele Vitolo
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Michele Vitolo
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Michele Vitolo
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Michele Vitolo
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Michele Vitolo
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Michele Vitolo
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P106
P1153
7006406191
P31
P496
0000-0001-8055-9645