Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells. - Wikidata - awgldk - TriplyDB

Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells.

Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells.

http://www.wikidata.org/entity/Q43179664

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Genome Engineering with TALE and CRISPR Systems in Neuroscience The Rise of CRISPR/Cas for Genome Editing in Stem Cells CRISPR/Cas9 and cancer targets: future possibilities and present challenges Resources for the design of CRISPR gene editing experiments How specific is CRISPR/Cas9 really?Use of designer nucleases for targeted gene and genome editing in plants Therapeutic genome editing: prospects and challenges Precision Chemistry for Precision Medicine Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9.The CRISPR/Cas9 genome editing methodology as a weapon against human viruses Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos.CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate.Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci.Human germ line editing-roles and responsibilities Crispr-mediated Gene Targeting of Human Induced Pluripotent Stem Cells A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice.Different Effects of sgRNA Length on CRISPR-mediated Gene Knockout Efficiency.The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat.Targeting cellular mRNAs translation by CRISPR-Cas9 Implications of human genetic variation in CRISPR-based therapeutic genome editing.Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies.In vivo blunt-end cloning through CRISPR/Cas9-facilitated non-homologous end-joining Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases.CRISPR/Cas9 genome editing in human pluripotent stem cells: Harnessing human genetics in a dish.Genome engineering tools for building cellular models of disease.Generating human hematopoietic stem cells in vitro -exploring endothelial to hematopoietic transition as a portal for stemness acquisition.Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity.CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes.Modification of the Genome of Domestic Animals.In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models.Functional screening of guide RNAs targeting the regulatory and structural HIV-1 viral genome for a cure of AIDS.Efficient CRISPR-Cas9-mediated generation of knockin human pluripotent stem cells lacking undesired mutations at the targeted locus.One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs.A pre-screening FISH-based method to detect CRISPR/Cas9 off-targets in mouse embryonic stem cells.Functional correction of dystrophin actin binding domain mutations by genome editing.A transatlantic perspective on 20 emerging issues in biological engineering.Gene Editing and Human Pluripotent Stem Cells: Tools for Advancing Diabetes Disease Modeling and Beta-Cell Development.

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Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells.

http://www.wikidata.org/entity/Q43179664

description

2014 nî lūn-bûn

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2014年學術文章

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name

Targeted and genome-wide seque ...... y of Cas9 in human stem cells.

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Targeted and genome-wide seque ...... y of Cas9 in human stem cells.

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type

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Targeted and genome-wide seque ...... y of Cas9 in human stem cells.

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Targeted and genome-wide seque ...... y of Cas9 in human stem cells.

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Targeted and genome-wide seque ...... y of Cas9 in human stem cells.

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Targeted and genome-wide seque ...... y of Cas9 in human stem cells.

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Nature Communications

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Targeted and genome-wide seque ...... y of Cas9 in human stem cells.

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Cheng-Zhong Zhang

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Christine Seidman

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Dennis Grishin

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Gang Wang

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Jason Homsy

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Jian-Bing Fan

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John Aach

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Jonathan Seidman

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Luhan Yang

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Raj Chari

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P2860

An integrated map of genetic variation from 1,092 human genomes

RNA-guided human genome engineering via Cas9

Heritable genome editing in C. elegans via a CRISPR-Cas9 system.

Multiplex genome engineering using CRISPR/Cas systems

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

Fast and accurate short read alignment with Burrows-Wheeler transform

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

A public resource facilitating clinical use of genomes

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

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10.1038/NCOMMS6507

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5

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George M. Church

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