Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.
about
Biologically inspired strategies for combating bacterial biofilmsEvolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKRA biochemical characterization of the DNA binding activity of the response regulator VicR from Streptococcus mutansNH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption.Efficacy of novel antibacterial compounds targeting histidine kinase YycG protein.Thiazolidione derivatives targeting the histidine kinase YycG are effective against both planktonic and biofilm-associated Staphylococcus epidermidis.Peptidoglycan crosslinking relaxation plays an important role in Staphylococcus aureus WalKR-dependent cell viability.Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence.Antibacterial and anti-biofilm activities of thiazolidione derivatives against clinical staphylococcus strains.Putative histidine kinase inhibitors with antibacterial effect against multi-drug resistant clinical isolates identified by in vitro and in silico screens.Anti-bacterial and Anti-biofilm Evaluation of Thiazolopyrimidinone Derivatives Targeting the Histidine Kinase YycG Protein of Staphylococcus epidermidis.Viable screening targets related to the bacterial cell wall.Virulence factor targeting of the bacterial pathogen Staphylococcus aureus for vaccine and therapeutics.Bacterial signal transduction networks via connectors and development of the inhibitors as alternative antibiotics.Isolation and characterization of signermycin B, an antibiotic that targets the dimerization domain of histidine kinase WalKDevelopment of an antivirulence drug against Streptococcus mutans: repression of biofilm formation, acid tolerance, and competence by a histidine kinase inhibitor, walkmycin CTwo-Component Signal Transduction Systems of Pathogenic Bacteria As Targets for Antimicrobial Therapy: An Overview.Waldiomycin, a novel WalK-histidine kinase inhibitor from Streptomyces sp. MK844-mF10.Angucycline antibiotic waldiomycin recognizes common structural motif conserved in bacterial histidine kinases.Evidence of Cross-Regulation in Two Closely Related Pyruvate-Sensing Systems in Uropathogenic Escherichia coli.Essential Two-Component Systems Regulating Cell Envelope Functions: Opportunities for Novel Antibiotic Therapies.The two-component signaling system VraSRSS is critical for multidrug resistance and full virulence in Streptococcus suis serotype 2.Screening for inhibitors of mutacin synthesis in Streptococcus mutans using fluorescent reporter strains.as a Prominent Resource of Future Anti-MRSA Drugs
P2860
Q27006003-CEECFC3D-5651-447C-9C45-49842A7FA0CAQ28477900-7DB27A2D-338B-4A29-B807-363FB02BDCE8Q28543046-9297B0D7-9BFB-4AF5-B179-030D82D5C026Q30795809-CE5458A7-68DD-451F-874B-E3C4E453BCF9Q33755387-0138E202-05AA-49E2-88D4-6C92B0706F57Q33828707-9A5EA33E-08BF-40D8-969A-E5A025F1FA2EQ33840892-E2ABFB13-CAB7-4A84-B2EC-5CE9E1E39A00Q34823364-008B6186-1134-4AC9-8E4D-E3383EDC12DEQ35050946-3E4F860F-D6E2-4C4E-B8C1-D90654BC1D30Q36898003-74B36D32-8F18-42DE-A6A9-53ACD05922EDQ37731045-76AEA64A-F4DD-4DE3-B5D3-6F4458497DE7Q38070780-FB61FEE4-80D6-4731-88F1-BB4339CB6E5BQ39022323-87458B5D-245E-4149-BEFF-4FCC7022D29FQ39457826-B02288B9-95AB-485F-9122-0D119A9C3EE3Q41811635-33CBD853-BA51-47A5-8CCC-EB036929DE41Q42099558-E55A5DE0-0025-4C56-819D-2BD8409A4D29Q42700482-EA1EE693-08FA-4957-944F-71C2549280FAQ44277852-03FA0FE1-3CBB-4572-B608-0CC326DA9B42Q48034939-42D9F804-F268-457D-9287-5BE6ACE14610Q48157607-36652D9C-0EAC-4B48-BDDE-C0EF249DBB11Q48371459-AD7345B0-82D4-4100-AB4E-765148824896Q52568715-7A06B914-BB50-4BAB-971C-91FE490FEA5DQ55042084-BA1B09B9-BA0E-4F39-AF81-EFC92D1EF90DQ57492422-D186A5EF-9B6C-491B-B945-FAA00F24E3B4
P2860
Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.
@en
Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.
@nl
type
label
Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.
@en
Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.
@nl
prefLabel
Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.
@en
Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.
@nl
P2093
P2860
P356
P1476
Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth
@en
P2093
Aaron Martin
Akihiro Doi
Ario Okada
John Quinn
Kunio Inoue
Masayuki Igarashi
Maya Umekita
Naoko Kinoshita
Ryutaro Utsumi
Takafumi Watanabe
P2860
P2888
P356
10.1038/JA.2009.128
P577
2010-01-08T00:00:00Z