Hydroxylation increases the neurotoxic potential of BDE-47 to affect exocytosis and calcium homeostasis in PC12 cells. - Wikidata - awgldk - TriplyDB

Hydroxylation increases the neurotoxic potential of BDE-47 to affect exocytosis and calcium homeostasis in PC12 cells.

Hydroxylation increases the neurotoxic potential of BDE-47 to affect exocytosis and calcium homeostasis in PC12 cells.

http://www.wikidata.org/entity/Q43206376

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Neurotoxicity of brominated flame retardants: (in)direct effects of parent and hydroxylated polybrominated diphenyl ethers on the (developing) nervous system A mechanistic view of polybrominated diphenyl ether (PBDE) developmental neurotoxicity Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts Quantification of Hydroxylated Polybrominated Diphenyl Ethers (OH-BDEs), Triclosan, and Related Compounds in Freshwater and Coastal Systems Contemporary 14C radiocarbon levels of oxygenated polybrominated diphenyl ethers (O-PBDEs) isolated in sponge-cyanobacteria associations PROXIMAL: a method for Prediction of Xenobiotic Metabolism Unraveling the bastarane and isobastarane oximo amide configurations and associated macrocycle conformations: implications of their influence on bioactivities Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior Ichthyotoxic brominated diphenyl ethers from a mixed assemblage of a red alga and cyanobacterium: structure clarification and biological properties.Polybrominated diphenyl ethers induce developmental neurotoxicity in a human in vitro model: evidence for endocrine disruption Hormone activity of hydroxylated polybrominated diphenyl ethers on human thyroid receptor-beta: in vitro and in silico investigations.Is decabromodiphenyl ether (BDE-209) a developmental neurotoxicant?Polybrominated diphenyl ethers in relation to autism and developmental delay: a case-control study.Exposures, mechanisms, and impacts of endocrine-active flame retardants.Aerobic biotransformation of polybrominated diphenyl ethers (PBDEs) by bacterial isolates Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells.Mouse cerebellar astrocytes protect cerebellar granule neurons against toxicity of the polybrominated diphenyl ether (PBDE) mixture DE-71.Characterization of Three Tetrabromobisphenol-S Derivatives in Mollusks from Chinese Bohai Sea: A Strategy for Novel Brominated Contaminants Identification Thyroid hormone metabolism and environmental chemical exposure.Developmental toxicity of the PBDE metabolite 6-OH-BDE-47 in zebrafish and the potential role of thyroid receptor β Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infants Biotransformation of BDE-47 to potentially toxic metabolites is predominantly mediated by human CYP2B6 A hydroxylated metabolite of flame-retardant PBDE-47 decreases the survival, proliferation, and neuronal differentiation of primary cultured adult neural stem cells and interferes with signaling of ERK5 MAP kinase and neurotrophin 3 Toxicity of the flame-retardant BDE-49 on brain mitochondria and neuronal progenitor striatal cells enhanced by a PTEN-deficient background Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels.Autism, Mitochondria and Polybrominated Diphenyl Ether Exposure.Molecular toxicology of polybrominated diphenyl ethers: nuclear hormone receptor mediated pathways.Modulation of cell viability, oxidative stress, calcium homeostasis, and voltage- and ligand-gated ion channels as common mechanisms of action of (mixtures of) non-dioxin-like polychlorinated biphenyls and polybrominated diphenyl ethers.Evaluation of DNA damage induced by 2 polybrominated diphenyl ether flame retardants (BDE-47 and BDE-209) in SK-N-MC cells.Bromination pattern of hydroxylated metabolites of BDE-47 affects their potency to release calcium from intracellular stores in PC12 cells.Comparison of PBDE congeners as inducers of oxidative stress in zebrafish.Photochemistry of tetra- through hexa-brominated dioxins/furans, hydroxylated and native BDEs in different media.Hexabromocyclododecane inhibits depolarization-induced increase in intracellular calcium levels and neurotransmitter release in PC12 cells.Comparative oxidative metabolism of BDE-47 and BDE-99 by rat hepatic microsomes.Inhibition of the Human ABC Efflux Transporters P-gp and BCRP by the BDE-47 Hydroxylated Metabolite 6-OH-BDE-47: Considerations for Human Exposure.Human Excretion of Polybrominated Diphenyl Ether Flame Retardants: Blood, Urine, and Sweat Study.From the Cover: BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms.Ligninase-mediated transformation of 4,4'-dibromodiphenyl ether (BDE 15).

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Hydroxylation increases the neurotoxic potential of BDE-47 to affect exocytosis and calcium homeostasis in PC12 cells.

http://www.wikidata.org/entity/Q43206376

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2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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Hydroxylation increases the ne ...... ium homeostasis in PC12 cells.

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Hydroxylation increases the ne ...... ium homeostasis in PC12 cells.

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Hydroxylation increases the ne ...... ium homeostasis in PC12 cells.

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Hydroxylation increases the ne ...... ium homeostasis in PC12 cells.

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Hydroxylation increases the ne ...... ium homeostasis in PC12 cells.

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Hydroxylation increases the ne ...... ium homeostasis in PC12 cells.

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Aart de Groot

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Ake Bergman

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Henk P M Vijverberg

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Martin van den Berg

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Milou M L Dingemans

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Regina G D M van Kleef

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Remco H S Westerink

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P2860

In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PDBEs, and polybrominated bisphenol A compounds.

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

Neurotoxicity of persistent organic pollutants: possible mode(s) of action and further considerations

Brominated flame retardants: a novel class of developmental neurotoxicants in our environment?

The PC12 cell as model for neurosecretion

Polybrominated diphenyl ethers (PBDEs) and bioaccumulative hydroxylated PBDE metabolites in young humans from Managua, Nicaragua

Store-operated calcium channels

Ca(2+) -independent vesicular catecholamine release in PC12 cells by nanomolar concentrations of Pb(2+).

Polychlorinated biphenyls induce caspase-dependent cell death in cultured embryonic rat hippocampal but not cortical neurons via activation of the ryanodine receptor.

Polybrominated diphenyl ethers: a case study for using biomonitoring data to address risk assessment questions

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