Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. - Wikidata - awgldk - TriplyDB

Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.

Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.

http://www.wikidata.org/entity/Q43213014

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Nephron Patterning: Lessons from Xenopus, Zebrafish, and Mouse Studies Kick it up a notch: Notch signaling and kidney fibrosis Organ In Vitro Culture: What Have We Learned about Early Kidney Development?Adipokines as a link between obesity and chronic kidney disease Molecular mechanisms of diabetic kidney disease Membrane trafficking in podocyte health and disease Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development In vivo notch signaling blockade induces abnormal spermatogenesis in the mouse Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1 Kidney organogenesis in the zebrafish: insights into vertebrate nephrogenesis and regeneration Development of the Mammalian Kidney Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule p120 catenin is required for normal renal tubulogenesis and glomerulogenesis Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation The prepattern transcription factor Irx3 directs nephron segment identity Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks Nephron organoids derived from human pluripotent stem cells model kidney development and injury The canonical Notch signaling pathway: unfolding the activation mechanism.Is the Epididymis a Series of Organs Placed Side By Side?Invasion of distal nephron precursors associates with tubular interconnection during nephrogenesis.Nephrons require Rho-kinase for proximal-distal polarity development The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros.The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage.Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development.Reduced Notch signaling leads to renal cysts and papillary microadenomas.Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways.Toward the development of podocyte-specific drugs.Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development Getting a notch closer to understanding diabetic kidney disease.Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling Deletions of 16q in Wilms tumors localize to blastemal-anaplastic cells and are associated with reduced expression of the IRXB renal tubulogenesis gene cluster.Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells.Induction and patterning of the metanephric nephron A bright single-cell resolution live imaging reporter of Notch signaling in the mouse.Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle

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P2860

Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.

http://www.wikidata.org/entity/Q43213014

description

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Notch2, but not Notch1, is req ...... tion in the mammalian nephron.

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Notch2, but not Notch1, is req ...... tion in the mammalian nephron.

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type

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Notch2, but not Notch1, is req ...... tion in the mammalian nephron.

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Notch2, but not Notch1, is req ...... tion in the mammalian nephron.

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Notch2, but not Notch1, is req ...... tion in the mammalian nephron.

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Notch2, but not Notch1, is req ...... ition in the mammalian nephron

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Achim Gossler

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Andrew P McMahon

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Kameswaran Surendran

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Karin Schuster-Gossler

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M Todd Valerius

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Mijin Kim

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P2860

NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway

Segmental expression of Notch and Hairy genes in nephrogenesis

Mutations in NOTCH1 cause aortic valve disease

Repression of Pax-2 by WT1 during normal kidney development

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

The paired-box transcription factor, PAX2, positively modulates expression of the Wilms' tumor suppressor gene (WT1)

Notch signaling controls multiple steps of pancreatic differentiation

Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes

Generalized lacZ expression with the ROSA26 Cre reporter strain

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