Structure-based design of DevR inhibitor active against nonreplicating Mycobacterium tuberculosis.
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Structure of the Mtb CarD/RNAP β-Lobes Complex Reveals the Molecular Basis of Interaction and Presents a Distinct DNA-Binding Domain for Mtb CarDQuorum sensing and biofilm formation in mycobacteria: role of c-di-GMP and methods to study this second messengerMycobacterium tuberculosis transcriptional adaptation, growth arrest and dormancy phenotype development is triggered by vitamin CMycobacterium tuberculosis DevR/DosR Dormancy Regulator Activation Mechanism: Dispensability of Phosphorylation, Cooperativity and Essentiality of α10 HelixDeterminants outside the DevR C-terminal domain are essential for cooperativity and robust activation of dormancy genes in Mycobacterium tuberculosis.The DosS-DosT/DosR Mycobacterial Sensor System.To catch a killer. What can mycobacterial models teach us about Mycobacterium tuberculosis pathogenesis?DevR (DosR) mimetic peptides impair transcriptional regulation and survival of Mycobacterium tuberculosis under hypoxia by inhibiting the autokinase activity of DevS sensor kinase.Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery.Appropriate DevR (DosR)-mediated signaling determines transcriptional response, hypoxic viability and virulence of Mycobacterium tuberculosisBroad spectrum pro-quorum-sensing molecules as inhibitors of virulence in vibrios.A screen to identify small molecule inhibitors of protein-protein interactions in mycobacteria.Nonquaternary poly(diallylammonium) polymers with different amine structure and their biocidal effect on Mycobacterium tuberculosis and Mycobacterium smegmatis.Adaptation to environmental stimuli within the host: two-component signal transduction systems of Mycobacterium tuberculosis.Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence.Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence.The progress made in determining the Mycobacterium tuberculosis structural proteomeTuberculosis drugs: new candidates and how to find more.Navigating tuberculosis drug discovery with target-based screening.The residue threonine 82 of DevR (DosR) is essential for DevR activation and function in Mycobacterium tuberculosis despite its atypical location.Targeting Phenotypically Tolerant Mycobacterium tuberculosis.Essentiality of DevR/DosR interaction with SigA for the dormancy survival program in Mycobacterium tuberculosis.The α10 helix of DevR, the Mycobacterium tuberculosis dormancy response regulator, regulates its DNA binding and activity.Drug targets in dormant Mycobacterium tuberculosis: can the conquest against tuberculosis become a reality?DevS/DosS sensor is bifunctional and its phosphatase activity precludes aerobic DevR/DosR regulon expression in Mycobacterium tuberculosis.Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design.Acetylation of lysine 182 inhibits the ability of Mycobacterium tuberculosis DosR to bind DNA and regulate gene expression during hypoxia.K182G substitution in DevR or C8G mutation in the Dev box impairs protein-DNA interaction and abrogates DevR-mediated gene induction in Mycobacterium tuberculosis
P2860
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P2860
Structure-based design of DevR inhibitor active against nonreplicating Mycobacterium tuberculosis.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
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2009年學術文章
@zh-hant
name
Structure-based design of DevR ...... ng Mycobacterium tuberculosis.
@en
Structure-based design of DevR ...... ng Mycobacterium tuberculosis.
@nl
type
label
Structure-based design of DevR ...... ng Mycobacterium tuberculosis.
@en
Structure-based design of DevR ...... ng Mycobacterium tuberculosis.
@nl
prefLabel
Structure-based design of DevR ...... ng Mycobacterium tuberculosis.
@en
Structure-based design of DevR ...... ng Mycobacterium tuberculosis.
@nl
P2093
P356
P1476
Structure-based design of DevR ...... ng Mycobacterium tuberculosis.
@en
P2093
Gautam R Desiraju
Jaya Sivaswami Tyagi
Rajesh Kumar Gupta
P304
P356
10.1021/JM900358Q
P407
P577
2009-10-01T00:00:00Z