about
SMAD2, SMAD3 and SMAD4 mutations in colorectal cancerKirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' studyLarge-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serumChecking the scoreboard: the impact of cancer genetics on clinical practice.Does MSI-low exist?Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.The relationship between hypomethylation and CpG island methylation in colorectal neoplasia.Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancerAltered promoter nucleosome positioning is an early event in gene silencing.Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancerDifferent APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas.Introducing research initiatives into healthcare: what do doctors think?Detection of K-ras point mutation by enriched PCR-colorimetric plate assay.Implementation of novel pyrosequencing assays to screen for common mutations of BRAF and KRAS in a cohort of sporadic colorectal cancers.Expression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both β-catenin dependent and independent Wnt signalling.Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer.Unconjugated antibodies for cancer therapy: lessons from the clinic.Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33.Germline epimutations of APC are not associated with inherited colorectal polyposis.Colorectal carcinomas arising in the hyperplastic polyposis syndrome progress through the chromosomal instability pathwayMGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa.C-kit mutations in gastrointestinal stromal tumours.Detection of allelic imbalance in MLH1 expression by pyrosequencing serves as a tool for the identification of germline defects in Lynch syndrome.Population-based molecular screening for Lynch syndrome: implications for personalized medicine.Poor-prognosis estrogen receptor-positive breast cancer identified by histopathologic subclassification.A correlation of the endoscopic characteristics of colonic laterally spreading tumours with genetic alterations.Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations.Histopathological and clinical evaluation of serrated adenomas of the colon and rectum.Adaptive Tutorials Versus Web-Based Resources in Radiology: A Mixed Methods Comparison of Efficacy and Student Engagement.PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer.Developmentally-regulated expression of murine K-ras isoforms.Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas.Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer.Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal TumorsInactivation of p16INK4a by CpG hypermethylation is not a frequent event in colorectal cancer.Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma.Institutional biobanking: an integral part of contemporary pathology practiceRelative Distribution of Folate Species Is Associated with Global DNA Methylation in Human Colorectal Mucosa
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
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հետազոտող
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name
Nicholas J. Hawkins
@ast
Nicholas J. Hawkins
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Nicholas J. Hawkins
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Nicholas J. Hawkins
@nl
Nicholas J. Hawkins
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type
label
Nicholas J. Hawkins
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Nicholas J. Hawkins
@en
Nicholas J. Hawkins
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Nicholas J. Hawkins
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Nicholas J. Hawkins
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prefLabel
Nicholas J. Hawkins
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Nicholas J. Hawkins
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Nicholas J. Hawkins
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Nicholas J. Hawkins
@nl
Nicholas J. Hawkins
@sl
P1053
A-8461-2008
P106
P1153
7102710449
P21
P31
P3829
P496
0000-0002-2204-3189