about
Physiology and pharmacology of the vanilloid receptorProtein-protein interaction antagonists as novel inhibitors of non-canonical polyubiquitylationBH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular componentsApaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicityModulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitorsSynthesis of a library of 3-oxopiperazinium and perhydro-3-oxo-1,4-diazepinium derivatives and identification of bioactive compounds.Antioxidant CR-6 protects against reperfusion injury after a transient episode of focal brain ischemia in rats.Prevention of in vivo excitotoxicity by a family of trialkylglycines, a novel class of neuroprotectants.Anti-Tat and anti-HIV activities of trimers of n-alkylglycines.Combinatorial chemistry in cancer research.Smallest peptoids with antiproliferative activity on human neoplastic cells.Synthesis of a positional scanning library of pentamers of N-alkylglycines assisted by microwave activation and validation via the identification of trypsin inhibitors.A semaphorin 3A inhibitor blocks axonal chemorepulsion and enhances axon regeneration.A fluorescent polarization-based assay for the identification of disruptors of the RCAN1-calcineurin A protein complex.A polymeric nanomedicine diminishes inflammatory events in renal tubular cellsPositional Scanning Synthesis of a Peptoid Library Yields New Inducers of Apoptosis that Target Karyopherins and Tubulin.Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier.Regioselective Synthesis of a Family of β-Lactams Bearing a Triazole Moiety as Potential Apoptosis InhibitorsMolecules that modulate Apaf-1 activity.Advances in modulating thermosensory TRP channels.Apaf1 inhibition promotes cell recovery from apoptosis.Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel.Cationic Peptides and Peptidomimetics Bind Glycosaminoglycans as Potential Sema3A Pathway Inhibitors.Nanoconjugates as intracorporeal neutralizers of bacterial endotoxins.A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint.The radical scavenger CR-6 protects SH-SY5Y neuroblastoma cells from oxidative stress-induced apoptosis: effect on survival pathways.First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases.Oxidative stress-induced apoptosis in retinal photoreceptor cells is mediated by calpains and caspases and blocked by the oxygen radical scavenger CR-6.Effect of triazine derivatives on neuronal nicotinic receptors.NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway.Vestibulotoxic properties of potential metabolites of allylnitrile.Triazine-based vanilloid 1 receptor open channel blockers: design, synthesis, evaluation, and SAR analysis.Participation of oxidative stress on rat middle cerebral artery changes induced by focal cerebral ischemia: beneficial effects of 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6).Potential implication of aniline derivatives in the Toxic Oil Syndrome (TOS).Metabolism of (R)- and (S)-3-(phenylamino)propane-1,2-diol in C57BL/6- and A/J-strain mice. Identification of new metabolites with potential toxicological significance to the toxic oil syndrome.Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome.The organochlorine pesticides gamma-hexachlorocyclohexane (lindane), alpha-endosulfan and dieldrin differentially interact with GABA(A) and glycine-gated chloride channels in primary cultures of cerebellar granule cells.Neuroprotection against excitotoxicity by N-alkylglycines in rat hippocampal neurons.In vitro metabolism of juvenile hormone III and juvenile hormone III bisepoxide by Drosophila melanogaster and mammalian cytosolic epoxide hydrolase.Studies on toxic oil syndrome: stereoselective hydrolysis of 3-(phenylamino)propane-1,2-diol esters by human pancreatic lipase.
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
@nl
հետազոտող
@hy
name
Angel Messeguer
@ast
Angel Messeguer
@en
Angel Messeguer
@es
Angel Messeguer
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type
label
Angel Messeguer
@ast
Angel Messeguer
@en
Angel Messeguer
@es
Angel Messeguer
@nl
prefLabel
Angel Messeguer
@ast
Angel Messeguer
@en
Angel Messeguer
@es
Angel Messeguer
@nl
P106
P1153
7004641278
P21
P31
P496
0000-0002-8358-9425