A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis.
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Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramideIntracellular trafficking of ceramide by ceramide transfer proteinCasein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelinA review of ceramide analogs as potential anticancer agentsChlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular developmentCritical Role of Virion-Associated Cholesterol and Sphingolipid in Hepatitis C Virus InfectionER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domainA role for sphingomyelin-rich lipid domains in the accumulation of phosphatidylinositol-4,5-bisphosphate to the cleavage furrow during cytokinesis.Sphingolipid transport: rafts and translocators.Vesicle-associated membrane protein-associated protein-A (VAP-A) interacts with the oxysterol-binding protein to modify export from the endoplasmic reticulum.Limonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum.Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner.CERT mediates intermembrane transfer of various molecular species of ceramides.Signaling at the Golgi.ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner.Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetesSphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.Development of a CERT START Domain-Ceramide HTRF Binding Assay and Application to Pharmacological Studies and Screening.Phosphoinositides and vesicular membrane trafficDecreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiation.Regulation of Golgi function via phosphoinositide lipids.Hijacking of Membrane Contact Sites by Intracellular Bacterial Pathogens.The cellular ceramide transport protein CERT promotes Chlamydia psittaci infection and controls bacterial sphingolipid uptake.Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins.Trafficking of Acetyl-C16-Ceramide-NBD with Long-Term Stability and No Cytotoxicity into the Golgi Complex.Chemistry and Biology of HPAs: A Family of Ceramide Trafficking Inhibitors.Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase: comparative analysis to glucosylceramide and sphingomyelin.Host sphingolipid biosynthesis as a target for hepatitis C virus therapy.Activation of the NLRP3 inflammasome in microglia: The role of ceramide.Dietary ganglioside reduces proinflammatory signaling in the intestine.The role of de novo ceramide synthesis in the mechanism of action of the tricyclic xanthate D609.Both sphingomyelin and cholesterol in the host cell membrane are essential for Rubella virus entry.Facile synthesis of the CERT inhibitor HPA-12 and some novel derivatives.Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications.Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain.Identification of novel CERT ligands as potential ceramide trafficking inhibitors.Asymmetric Synthesis and Binding Study of New Long-Chain HPA-12 Analogues as Potent Ligands of the Ceramide Transfer Protein CERT.Activation of neutral sphingomyelinase 2 by starvation induces cell-protective autophagy via an increase in Golgi-localized ceramide.
P2860
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P2860
A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
A novel inhibitor of ceramide ...... te of sphingomyelin synthesis.
@en
A novel inhibitor of ceramide ...... te of sphingomyelin synthesis.
@nl
type
label
A novel inhibitor of ceramide ...... te of sphingomyelin synthesis.
@en
A novel inhibitor of ceramide ...... te of sphingomyelin synthesis.
@nl
prefLabel
A novel inhibitor of ceramide ...... te of sphingomyelin synthesis.
@en
A novel inhibitor of ceramide ...... te of sphingomyelin synthesis.
@nl
P2093
P2860
P356
P1476
A novel inhibitor of ceramide ...... ite of sphingomyelin synthesis
@en
P2093
H Ishitani
H Kitagawa
M Fukasawa
M Nishijima
S Kobayashi
P2860
P304
43994-44002
P356
10.1074/JBC.M104884200
P407
P577
2001-09-06T00:00:00Z