Alkylation of polyguanylic acid at the 2-amino group and phosphate by the potent mutagen (+/-)-7beta,8alpha-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
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Role of the modulation of CYP1A1 expression and activity in chemopreventionDetection of phosphodiester adducts formed by the reaction of benzo[a]pyrene diol epoxide with 2'-deoxynucleotides using collision-induced dissociation electrospray ionization tandem mass spectrometryExcision repair of benzo[a]pyrene-deoxyguanosine adducts in baby hamster kidney 21/C13 cells and in secondary mouse embryo fibroblasts C57BL/6JMutagenicity and cytotoxicity of benz[alpha]anthracene diol epoxides and tetrahydro-epoxides: exceptional activity of the bay region 1,2-epoxidesFormation and persistence of benzo(a)pyrene metabolite-DNA adducts.Chloride ions catalyze the formation of cis adducts in the binding of anti-benzo[a]pyrene diol epoxide to nucleic acids.Identification of the major adducts formed by reaction of benzo(a)pyrene diol epoxide with DNA in vitroEquilibrium binding of carcinogens and antitumor antibiotics to DNA: site selectivity, cooperativity, allosterism.Benzo[a]pyrene diol epoxide-DNA cis adduct formation through a trans chlorohydrin intermediate.Hydrolysis of benzo[a]pyrene diol epoxide and its covalent binding to DNA proceed through similar rate-determining steps.Solution conformation of the major adduct between the carcinogen (+)-anti-benzo[a]pyrene diol epoxide and DNAGeneration of nucleic acid structures and binding of molecules to DNA.Selectivity of alkylation and aralkylation of nucleic acid components.Computer modelling studies of the covalent interactions between DNA and the enantiomers of anti-7,8-diol,9,10-epoxy-benzo[a]pyrene.Diverse chemical carcinogens fail to induce G(1) arrest in MCF-7 cells.DNA strand breaks induced by configurationally isomeric hydrocarbon diol epoxides.Interactions of molecules with nucleic acids. X. Covalent intercalative binding of the carcinogenic BPDE I(+) to kinked DNA.Toxic agents resulting from the oxidative metabolism of steroid hormones and drugs.Characterization and Quantitation of Benzo[A]pyrene-DNA Adducts by Solid-Matrix LuminescenceDouble-stranded DNA stereoselectively binds benzo(a)pyrene diol epoxidesStructures of benzo(a)pyrene–nucleic acid adducts formed in human and bovine bronchial explants
P2860
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P2860
Alkylation of polyguanylic acid at the 2-amino group and phosphate by the potent mutagen (+/-)-7beta,8alpha-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
description
1976 nî lūn-bûn
@nan
1976年の論文
@ja
1976年学术文章
@wuu
1976年学术文章
@zh
1976年学术文章
@zh-cn
1976年学术文章
@zh-hans
1976年学术文章
@zh-my
1976年学术文章
@zh-sg
1976年學術文章
@yue
1976年學術文章
@zh-hant
name
Alkylation of polyguanylic aci ...... 9,10-tetrahydrobenzo[a]pyrene.
@en
Alkylation of polyguanylic aci ...... 9,10-tetrahydrobenzo[a]pyrene.
@nl
type
label
Alkylation of polyguanylic aci ...... 9,10-tetrahydrobenzo[a]pyrene.
@en
Alkylation of polyguanylic aci ...... 9,10-tetrahydrobenzo[a]pyrene.
@nl
prefLabel
Alkylation of polyguanylic aci ...... 9,10-tetrahydrobenzo[a]pyrene.
@en
Alkylation of polyguanylic aci ...... 9,10-tetrahydrobenzo[a]pyrene.
@nl
P2093
P356
P1476
Alkylation of polyguanylic aci ...... 9,10-tetrahydrobenzo[a]pyrene.
@en
P2093
P304
P356
10.1021/JA00437A061
P407
P577
1976-10-01T00:00:00Z