Contribution of enzyme-phosphoribosyl contacts to catalysis by orotidine 5'-phosphate decarboxylase.
about
Crystal structures of inhibitor complexes reveal an alternate binding mode in orotidine-5'-monophosphate decarboxylaseIndependent saturation of three TrpRS subsites generates a partially assembled state similar to those observed in molecular simulationsMechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization ,Structural determinants for the inhibitory ligands of orotidine-5′-monophosphate decarboxylaseConformational Changes in Orotidine 5′-Monophosphate Decarboxylase: A Structure-Based Explanation for How the 5′-Phosphate Group Activates the EnzymeSubstrate Distortion Contributes to the Catalysis of Orotidine 5′-Monophosphate DecarboxylaseMechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase.Activation of R235A mutant orotidine 5'-monophosphate decarboxylase by the guanidinium cation: effective molarity of the cationic side chain of Arg-235Determination of the amino acid sequence requirements for catalysis by the highly proficient orotidine monophosphate decarboxylase.Molecular dynamic study of orotidine-5'-monophosphate decarboxylase in ground state and in intermediate state: a role of the 203-218 loop dynamics.On catalytic preorganization in oxyanion holes: highlighting the problems with the gas-phase modeling of oxyanion holes and illustrating the need for complete enzyme models.Enzyme architecture: deconstruction of the enzyme-activating phosphodianion interactions of orotidine 5'-monophosphate decarboxylase.Indiscriminate binding by orotidine 5'-phosphate decarboxylase of uridine 5'-phosphate derivatives with bulky anionic c6 substituents.Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions.Orotic acid decarboxylation in water and nonpolar solvents: a potential role for desolvation in the action of OMP decarboxylase.A substrate in pieces: allosteric activation of glycerol 3-phosphate dehydrogenase (NAD+) by phosphite dianion.A role for flexible loops in enzyme catalysis.Hydrogen-bond stabilization in oxyanion holes: grand jeté to three dimensions.Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: effect of solvent viscosity on kinetic constants.Dissecting a charged network at the active site of orotidine-5'-phosphate decarboxylase.The acidity of uracil and uracil analogs in the gas phase: four surprisingly acidic sites and biological implications.
P2860
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P2860
Contribution of enzyme-phosphoribosyl contacts to catalysis by orotidine 5'-phosphate decarboxylase.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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name
Contribution of enzyme-phospho ...... ne 5'-phosphate decarboxylase.
@en
Contribution of enzyme-phospho ...... ne 5'-phosphate decarboxylase.
@nl
type
label
Contribution of enzyme-phospho ...... ne 5'-phosphate decarboxylase.
@en
Contribution of enzyme-phospho ...... ne 5'-phosphate decarboxylase.
@nl
prefLabel
Contribution of enzyme-phospho ...... ne 5'-phosphate decarboxylase.
@en
Contribution of enzyme-phospho ...... ne 5'-phosphate decarboxylase.
@nl
P2093
P356
P1433
P1476
Contribution of enzyme-phospho ...... ine 5'-phosphate decarboxylase
@en
P2093
B G Miller
R Wolfenden
P304
P356
10.1021/BI000818X
P407
P577
2000-07-01T00:00:00Z