Dual roles of mitochondrial K(ATP) channels in diazoxide-mediated protection in isolated rabbit hearts.
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Mitochondrial K(ATP) channel activation reduces anoxic injury by restoring mitochondrial membrane potentialPro- and Antiarrhythmic Actions of Sulfonylureas: Mechanistic and Clinical Evidence.Activation of ATP-dependent potassium channels is a trigger but not a mediator of ischaemic preconditioning in pigs.Remodeling of atrial ATP-sensitive K⁺ channels in a model of salt-induced elevated blood pressure.Evidence for mitochondrial K+ channels and their role in cardioprotection.The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic.Multiplicity of effectors of the cardioprotective agent, diazoxide.Mice lacking sulfonylurea receptor 2 (SUR2) ATP-sensitive potassium channels are resistant to acute cardiovascular stress.Diazoxide acts more as a PKC-epsilon activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury.Pharmacological preconditioning by diazoxide downregulates cardiac L-type Ca(2+) channels.The role of mitochondrial K(ATP) channels in the antiarrhythmic effects of ischaemic preconditioning in dogs.Role of mitochondrial ATP-sensitive potassium channel-mediated PKC-ε in delayed protection against myocardial ischemia/reperfusion injury in isolated hearts of sevoflurane-preconditioned rats.Inhibition of mitochondrial calcium-independent phospholipase A2 (iPLA2) attenuates mitochondrial phospholipid loss and is cardioprotective.Diazoxide attenuates ischemia/reperfusion injury via upregulation of heme oxygenase-1 after liver transplantation in rats.Roles of KATP channels in delayed cardioprotection and intracellular Ca(2+) in the rat heart as revealed by kappa-opioid receptor stimulation with U50488H.Selective blockade of mitochondrial K(ATP) channels does not impair myocardial oxygen consumption.Cardiac preconditioning with 4-h, 17 degrees C ischemia reduces [Ca(2+)](i) load and damage in part via K(ATP) channel opening.Ketamine abolishes ischemic preconditioning through inhibition of K(ATP) channels in rabbit hearts.Mechanisms by which opening the mitochondrial ATP- sensitive K(+) channel protects the ischemic heart.ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases.Acetylcholine but not adenosine triggers preconditioning through PI3-kinase and a tyrosine kinase.Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine.The effects of ischaemic preconditioning, diazoxide and 5-hydroxydecanoate on rat heart mitochondrial volume and respiration.Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors.Protective role of gap junctions in preconditioning against myocardial infarction.Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits.Mitochondrial KATP channels in hindlimb remote ischemic preconditioning of skeletal muscle against infarction.Nitric oxide-cGMP-protein kinase G signaling pathway induces anoxic preconditioning through activation of ATP-sensitive K+ channels in rat hearts.
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P2860
Dual roles of mitochondrial K(ATP) channels in diazoxide-mediated protection in isolated rabbit hearts.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Dual roles of mitochondrial K
@nl
Dual roles of mitochondrial K( ...... ion in isolated rabbit hearts.
@en
type
label
Dual roles of mitochondrial K
@nl
Dual roles of mitochondrial K( ...... ion in isolated rabbit hearts.
@en
prefLabel
Dual roles of mitochondrial K
@nl
Dual roles of mitochondrial K( ...... ion in isolated rabbit hearts.
@en
P2093
P2860
P1476
Dual roles of mitochondrial K( ...... ion in isolated rabbit hearts.
@en
P2093
P2860
P304
P356
10.1152/AJPHEART.2001.280.1.H246
P577
2001-01-01T00:00:00Z