Mutations distal to the substrate site can affect varicella zoster virus thymidine kinase activity: implications for drug design.
about
Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encodedIn vitro-selected drug-resistant varicella-zoster virus mutants in the thymidine kinase and DNA polymerase genes yield novel phenotype-genotype associations and highlight differences between antiherpesvirus drugs.Effects of non-catalytic, distal amino acid residues on activity of E. coli DinB (DNA polymerase IV).Phenotypic and genetic characterization of varicella-zoster virus mutants resistant to acyclovir, brivudine and/or foscarnet.Engineering of a bacterial tyrosinase for improved catalytic efficiency towards D-tyrosine using random and site directed mutagenesis approaches.Mutational, inhibitory and microcalorimetric analyses of Plasmodium falciparum TMP kinase. Implications for drug discovery.Uncovering the role of the flexible C-terminal tail: A model study with Strep-tagged GFP.
P2860
Q33786307-48E5AA11-418D-4172-9E3A-2829E73C8558Q35826062-74B32144-302E-4311-B8AB-1E90CC6BD0DCQ38321122-E74FA7E2-C59C-460A-B731-CDAC69E57D97Q39581584-8922A07E-2378-4940-85A1-F9853B2BE185Q44707154-226CA63E-1350-4235-A9F0-F4EA69331B6EQ46173578-D528A8E0-BD9E-4424-A643-B5CD2D13E5C1Q52690946-DFAD357D-2961-4796-88CA-D3F49747D2AF
P2860
Mutations distal to the substrate site can affect varicella zoster virus thymidine kinase activity: implications for drug design.
description
2006 nî lūn-bûn
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name
Mutations distal to the substr ...... implications for drug design.
@en
Mutations distal to the substr ...... implications for drug design.
@nl
type
label
Mutations distal to the substr ...... implications for drug design.
@en
Mutations distal to the substr ...... implications for drug design.
@nl
prefLabel
Mutations distal to the substr ...... implications for drug design.
@en
Mutations distal to the substr ...... implications for drug design.
@nl
P50
P356
P1476
Mutations distal to the substr ...... implications for drug design.
@en
P2093
David K Stammers
P304
P356
10.1124/MOL.106.023002
P577
2006-03-23T00:00:00Z