Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity.
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Ras-catalyzed hydrolysis of GTP: a new perspective from model studiesGPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Galpha subunit and functions in a Ras-independent pathway.A high throughput screen for RGS proteins using steady state monitoring of free phosphate formationMechanism of GTP hydrolysis by G-protein alpha subunitsCloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1.Allosteric determinants in guanine nucleotide-binding proteins.Stimulation of human umbilical vein endothelial cell proliferation by A2-adenosine and beta 2-adrenoceptors.Persistent membrane association of activated and depalmitoylated G protein alpha subunitsInduced nucleotide specificity in a GTPase.The extreme C-terminal region of Gαs differentially couples to the luteinizing hormone and beta2-adrenergic receptors.Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex.Gsalpha-selective G protein antagonists.Cellular signaling by an agonist-activated receptor/Gs alpha fusion protein.Enhanced sensitivity to cholera toxin in ADP-ribosylarginine hydrolase-deficient mice.Prenyl modification of guanine nucleotide regulatory protein gamma 2 subunits is not required for interaction with the transducin alpha subunit or rhodopsinStimulation of human thyroid growth via the inhibitory guanine nucleotide binding (G) protein Gi: constitutive expression of the G-protein alpha subunit Gi alpha-1 in autonomous adenoma.Genetic and physical interactions between Gα subunits and components of the Gβγ dimer of heterotrimeric G proteins in Neurospora crassa.Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation.Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome.Activation-induced subcellular redistribution of Gs alpha.A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells.Expression of two human beta-adrenergic receptors in Escherichia coli: functional interaction with two forms of the stimulatory G protein.Toxin mediated diarrhea in the 21 century: the pathophysiology of intestinal ion transport in the course of ETEC, V. cholerae and rotavirus infection.Invited review: Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis.Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins.Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegansPhosphorylation of the spliced variant forms of the recombinant stimulatory guanine-nucleotide-binding regulatory protein (Gs alpha) by protein kinase C.Mutation of cysteine 214 in Gi1 alpha subunit abolishes its endogenous GTPase activity.Gi3 does not contribute to the inhibition of adenylate cyclase when stimulation of an alpha 2-adrenergic receptor causes activation of both Gi2 and Gi3.Interactions of purified bovine brain A1-adenosine receptors with G-proteins. Reciprocal modulation of agonist and antagonist binding.The molecular cloning of the squid (Loligo forbesi) visual Gq-alpha subunit and its expression in Saccharomyces cerevisiae.GTPase mechanism and function: new insights from systematic mutational analysis of the phosphate-binding loop residue Ala30 of Rab5.High-glucose incubation of human umbilical-vein endothelial cells does not alter expression and function either of G-protein alpha-subunits or of endothelial NO synthase.Concurrent down-regulation of IP prostanoid receptors and the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs) during prolonged exposure of neuroblastoma x glioma cells to prostanoid agonists. Quantification and functional im
P2860
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P2860
Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh-hant
name
Mutations of GS alpha designed ...... lt in loss of GTPase activity.
@en
Mutations of GS alpha designed ...... lt in loss of GTPase activity.
@nl
type
label
Mutations of GS alpha designed ...... lt in loss of GTPase activity.
@en
Mutations of GS alpha designed ...... lt in loss of GTPase activity.
@nl
prefLabel
Mutations of GS alpha designed ...... lt in loss of GTPase activity.
@en
Mutations of GS alpha designed ...... lt in loss of GTPase activity.
@nl
P1476
Mutations of GS alpha designed ...... lt in loss of GTPase activity.
@en
P2093
A G Gilman
M Freissmuth
P304
21907-21914
P407
P577
1989-12-01T00:00:00Z