A regulatory hydrophobic area in the flexible joint region of plasminogen activator inhibitor-1, defined with fluorescent activity-neutralizing ligands. Ligand-induced serpin polymerization.
about
Structural Basis for Recognition of Urokinase-type Plasminogen Activator by Plasminogen Activator Inhibitor-1Characterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 That Accelerates the Transition into the Latent ConformationMechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1A redox-sensitive loop regulates plasminogen activator inhibitor type 2 (PAI-2) polymerizationInhibition of plasminogen activator inhibitor-1 binding to endocytosis receptors of the low-density-lipoprotein receptor family by a peptide isolated from a phage display library.Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1The molecular basis for anti-proteolytic and non-proteolytic functions of plasminogen activator inhibitor type-1: roles of the reactive centre loop, the shutter region, the flexible joint region and the small serpin fragment.Chemical Antagonists of Plasminogen Activator Inhibitor-1: Mechanisms of Action and Therapeutic Potential in Vascular Disease.alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies.Low Molecular Weight Antagonists of Plasminogen Activator Inhibitor-1: Therapeutic Potential in Cardiovascular DiseaseKinetic evidence that allosteric activation of antithrombin by heparin is mediated by two sequential conformational changes.Conformational preludes to the latency transition in PAI-1 as determined by atomistic computer simulations and hydrogen/deuterium-exchange mass spectrometry.Construction of a plasminogen activator inhibitor-1 variant without measurable affinity to vitronectin but otherwise normal.Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herb Zanthoxylum nitidum var. tomentosumBiochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1.Plasminogen activator inhibitor-1 polymers, induced by inactivating amphipathic organochemical ligands.Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1.Stretched extracellular matrix proteins turn fouling and are functionally rescued by the chaperones albumin and casein.Importance of the amino-acid composition of the shutter region of plasminogen activator inhibitor-1 for its transitions to latent and substrate forms.Mapping of the epitope of a monoclonal antibody protecting plasminogen activator inhibitor-1 against inactivating agents.Elucidation of a novel epitope of a substrate-inducing monoclonal antibody against the serpin PAI-1.Site-directed targeting of plasminogen activator inhibitor-1 as an example for a novel approach in rational drug design.Cloning and paratope analysis of an antibody fragment, a rational approach for the design of a PAI-1 inhibitor.Characterization and comparative evaluation of a structurally unique PAI-1 inhibitor exhibiting oral in-vivo efficacy.
P2860
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P2860
A regulatory hydrophobic area in the flexible joint region of plasminogen activator inhibitor-1, defined with fluorescent activity-neutralizing ligands. Ligand-induced serpin polymerization.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
A regulatory hydrophobic area ...... induced serpin polymerization.
@en
A regulatory hydrophobic area ...... induced serpin polymerization.
@nl
type
label
A regulatory hydrophobic area ...... induced serpin polymerization.
@en
A regulatory hydrophobic area ...... induced serpin polymerization.
@nl
prefLabel
A regulatory hydrophobic area ...... induced serpin polymerization.
@en
A regulatory hydrophobic area ...... induced serpin polymerization.
@nl
P2093
P2860
P356
P1476
A regulatory hydrophobic area ...... induced serpin polymerization.
@en
P2093
A Christensen
A P Einholm
K E Pedersen
P A Andreasen
R W Nielsen
P2860
P304
13077-13086
P356
10.1074/JBC.M009024200
P407
P577
2001-01-25T00:00:00Z