Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.
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The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCPSirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cellsEpac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretionUncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen speciesDynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cellsGlucocorticoids modulate amino acid-induced translation initiation in human skeletal muscle.Uncoupling proteins--a new family of proteins with unknown function.Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid.UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells.Increased hepatic UCP2 expression in rats with nonalcoholic steatohepatitis is associated with upregulation of Sp1 binding to its motif within the proximal promoter region.Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function.Radioactive Iodine Therapy and Glucose Tolerance.Glucolipotoxicity of the pancreatic beta cell.Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities.Uncoupling protein 2 regulates daily rhythms of insulin secretion capacity in MIN6 cells and isolated islets from male miceCellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipinMitochondrial uncoupling and lifespan.Uncoupling protein 2 gene polymorphisms are associated with obesity.SREBF1 gene variations modulate insulin sensitivity in response to a fish oil supplementationMolecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction.Effects of free fatty acids on insulin secretion in obesity.Study of the Effect of Panax Ginseng versus Gliclazide on Hyperglycaemia Induced by Dexamethasone in Experimental AnimalsAmerican ginseng stimulates insulin production and prevents apoptosis through regulation of uncoupling protein-2 in cultured beta cells.Genetic Variance in Uncoupling Protein 2 in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional -866G>A Promoter Variant (rs659366)Uncoupling protein 3 (UCP3) modulates the activity of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by decreasing mitochondrial ATP productionHyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in miceLoss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells.Dyslipidemia, insulin resistance and dietary fat intake in obese and normal weight adolescents: the role of uncoupling protein 2 -866G/A gene polymorphism.Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice.Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs.Circadian control of β-cell function and stress responses.Nutrigenomics, beta-cell function and type 2 diabetesBmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in miceGlucolipotoxicity: fuel excess and beta-cell dysfunction.UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival.Mitochondrial uncoupling proteins regulate angiotensin-converting enzyme expression: crosstalk between cellular and endocrine metabolic regulators suggested by RNA interference and genetic studiesUncoupling proteins: role in insulin resistance and insulin insufficiencyMitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3?
P2860
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P2860
Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Overexpression of uncoupling p ...... lin secretion from rat islets.
@en
Overexpression of uncoupling p ...... lin secretion from rat islets.
@nl
type
label
Overexpression of uncoupling p ...... lin secretion from rat islets.
@en
Overexpression of uncoupling p ...... lin secretion from rat islets.
@nl
prefLabel
Overexpression of uncoupling p ...... lin secretion from rat islets.
@en
Overexpression of uncoupling p ...... lin secretion from rat islets.
@nl
P2093
P50
P1433
P1476
Overexpression of uncoupling p ...... ulin secretion from rat islets
@en
P2093
P304
P356
10.2337/DIABETES.48.7.1482
P407
P577
1999-07-01T00:00:00Z