Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity.
about
Integrated structure- and ligand-based in silico approach to predict inhibition of cytochrome P450 2D6.Metabolite profile resulting from the activation/inactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-methyltetrahydro-β-carboline by oxidative enzymes.New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.Substituted imidazole of 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates cytochrome P450 2D6 by protein adductionInsights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesisOxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps.CYP isoform specificity toward drug metabolism: analysis using common feature hypothesis.Structure and function of the cytochrome P450 peroxygenase enzymes.Toward reduction in animal sacrifice for drugs: molecular modeling of Macaca fascicularis P450 2C20 for virtual screening of Homo sapiens P450 2C8 substrates.
P2860
Q30378479-99A0B1AC-E448-496A-9F3E-58E3DF5F6AA4Q34655711-3BC59175-5936-4CFE-B884-4ED456598526Q34994964-42AFB1C1-3034-401A-A708-C8518164F809Q35002484-B0601E64-1223-429D-93D5-9B3EBAB71898Q36497020-7438C1BD-1C4E-453D-9372-A9430D5131BCQ37433387-C9D32037-391E-4152-A774-DE452B8A1CA2Q44047581-5DE2724C-E1C5-4A59-A5FF-12C23E0FD6F4Q44784776-16E76187-FC38-4294-857A-B3C5666819EDQ50063926-F7B160F8-E23E-4A92-98A8-B79E3208F3EFQ51068004-4211E70A-DAEB-4D3F-91B2-A3B6E558F4DF
P2860
Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Diversity in mechanisms of sub ...... in catalytic regioselectivity.
@en
Diversity in mechanisms of sub ...... in catalytic regioselectivity.
@nl
type
label
Diversity in mechanisms of sub ...... in catalytic regioselectivity.
@en
Diversity in mechanisms of sub ...... in catalytic regioselectivity.
@nl
prefLabel
Diversity in mechanisms of sub ...... in catalytic regioselectivity.
@en
Diversity in mechanisms of sub ...... in catalytic regioselectivity.
@nl
P2093
P2860
P356
P1476
Diversity in mechanisms of sub ...... in catalytic regioselectivity.
@en
P2093
P2860
P304
39553-39561
P356
10.1074/JBC.M106841200
P407
P577
2001-08-16T00:00:00Z