Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function.
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BMPR2 spruces up the endothelium in pulmonary hypertensionAbnormal trafficking of endogenously expressed BMPR2 mutant allelic products in patients with heritable pulmonary arterial hypertensionMicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension.Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.Key role of the endothelial TGF-β/ALK1/endoglin signaling pathway in humans and rodents pulmonary hypertension.Regulation of bone morphogenetic protein 9 (BMP9) by redox-dependent proteolysis.Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension.Adult-specific systemic over-expression reveals novel in vivo effects of the soluble forms of ActRIIA, ActRIIB and BMPRII.Physiologic and molecular consequences of endothelial Bmpr2 mutation.BMP pathway regulation of and by macrophages.Rescuing the BMPR2 signaling axis in pulmonary arterial hypertensionIdiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression.Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertensionTo be EndMT or not to be, that is the question in pulmonary hypertensionRNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension.Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertensionExpression of mutant bone morphogenetic protein receptor II worsens pulmonary hypertension secondary to pulmonary fibrosis.The promise of recombinant BMP ligands and other approaches targeting BMPR-II in the treatment of pulmonary arterial hypertensionEndothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension.MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling.Anticipated classes of new medications and molecular targets for pulmonary arterial hypertensionGenetics and the molecular pathogenesis of pulmonary arterial hypertension.Rho GTPases in the regulation of pulmonary vascular barrier function.Regulators and effectors of bone morphogenetic protein signalling in the cardiovascular system.Connexin-mediated regulation of the pulmonary vasculature.Myeloid-derived Suppressor Cells are Necessary for Development of Pulmonary Hypertension.BMPRII influences the response of pulmonary microvascular endothelial cells to inflammatory mediators.Restoring BMPRII functions in pulmonary arterial hypertension: opportunities, challenges and limitations.BMP type II receptor as a therapeutic target in pulmonary arterial hypertension.Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II.Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2.Transient Receptor Potential Channel 4 Encodes a Vascular Permeability Defect and High-Frequency Ca(2+) Transients in Severe Pulmonary Arterial Hypertension.Pulmonary microRNA profiling in a mouse model of ventilator-induced lung injury.Endothelial hyperpermeability in severe pulmonary arterial hypertension: role of store-operated calcium entry.Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium.Elevated CCN2 expression in scleroderma: a putative role for the TGFβ accessory receptors TGFβRIII and endoglin.Different patterns of pulmonary vascular disease induced by type 1 diabetes and moderate hypoxia in rats.Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice.Induced Pluripotent Stem Cell Model of Pulmonary Arterial Hypertension Reveals Novel Gene Expression and Patient Specificity.
P2860
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P2860
Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Bone morphogenetic protein rec ...... thelial cell barrier function.
@en
Bone morphogenetic protein rec ...... thelial cell barrier function.
@nl
type
label
Bone morphogenetic protein rec ...... thelial cell barrier function.
@en
Bone morphogenetic protein rec ...... thelial cell barrier function.
@nl
prefLabel
Bone morphogenetic protein rec ...... thelial cell barrier function.
@en
Bone morphogenetic protein rec ...... thelial cell barrier function.
@nl
P2093
P1433
P1476
Bone morphogenetic protein rec ...... thelial cell barrier function.
@en
P2093
Alan M Holmes
Christoph Walker
David C Budd
David M Rodman
Loredana I Ciuclan
Victoria J Burton
P304
P356
10.1182/BLOOD-2010-05-285973
P407
P577
2010-08-19T00:00:00Z