The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity. - Wikidata - awgldk - TriplyDB

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.

http://www.wikidata.org/entity/Q43851423

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Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration Mouse models of acute exacerbations of allergic asthma CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection Respiratory syncytial virus infections enhance cigarette smoke induced COPD in mice Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression.Identification of sexually dimorphic genes in the neonatal mouse cortex and hippocampus Airway Inflammation after Bronchial Thermoplasty for Severe Asthma.From the Biology of PP2A to the PADs for Therapy of Hematologic Malignancies Secreted phosphoprotein 1 is a determinant of lung function development in mice.Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation Intranasal administration of recombinant TRAIL down-regulates CXCL-1/KC in an ovalbumin-induced airway inflammation murine model The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development.Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma.Midline 1 controls polarization and migration of murine cytotoxic T cells.CCL7 and IRF-7 Mediate Hallmark Inflammatory and IFN Responses following Rhinovirus 1B Infection Basal protein phosphatase 2A activity restrains cytokine expression: role for MAPKs and tristetraprolin A systematic evaluation of the safety and toxicity of fingolimod for its potential use in the treatment of acute myeloid leukaemia.Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia.Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice TNF-related apoptosis-inducing ligand (TRAIL) regulates midline-1, thymic stromal lymphopoietin, inflammation, and remodeling in experimental eosinophilic esophagitis Role of Aspergillus fumigatus in Triggering Protease-Activated Receptor-2 in Airway Epithelial Cells and Skewing the Cells toward a T-helper 2 Bias.Virus/allergen interactions in asthma.Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases The emerging role of the ubiquitin proteasome in pulmonary biology and disease.X-linked microtubule-associated protein, Mid1, regulates axon development.The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells.A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma.Pulmonary immunity during respiratory infections in early life and the development of severe asthma.Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.Rhinovirus-bacteria coexposure synergistically induces CCL20 production from human bronchial epithelial cells.Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease.Downregulating galectin-3 inhibits proinflammatory cytokine production by human monocyte-derived dendritic cells via RNA interference.A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling Mouse models of severe asthma: Understanding the mechanisms of steroid resistance, tissue remodelling and disease exacerbation.T Cells in Allergic Asthma: Key Players Beyond the Th2 Pathway.Modeling TH 2 responses and airway inflammation to understand fundamental mechanisms regulating the pathogenesis of asthma.Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease.MARCH1 E3 Ubiquitin Ligase Dampens the Innate Inflammatory Response by Modulating Monocyte Functions in Mice.Myeloid-Specific Gene Deletion of Protein Phosphatase 2A Magnifies MyD88- and TRIF-Dependent Inflammation following Endotoxin Challenge.

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P2860

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.

http://www.wikidata.org/entity/Q43851423

description

2013 nî lūn-bûn

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

@zh-cn

2013年学术文章

@zh-hans

2013年学术文章

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2013年学术文章

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2013年學術文章

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2013年學術文章

@zh-hant

name

The E3 ubiquitin ligase midlin ...... otein phosphatase 2A activity.

@en

The E3 ubiquitin ligase midlin ...... otein phosphatase 2A activity.

@nl

type

label

The E3 ubiquitin ligase midlin ...... otein phosphatase 2A activity.

@en

The E3 ubiquitin ligase midlin ...... otein phosphatase 2A activity.

@nl

prefLabel

The E3 ubiquitin ligase midlin ...... otein phosphatase 2A activity.

@en

The E3 ubiquitin ligase midlin ...... otein phosphatase 2A activity.

@nl

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Nature Medicine

P1476

The E3 ubiquitin ligase midlin ...... rotein phosphatase 2A activity

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P2093

Adam Collison

http://www.w3.org/2001/XMLSchema#string

Ana Pereira de Siqueira

http://www.w3.org/2001/XMLSchema#string

Helen Carpenter

http://www.w3.org/2001/XMLSchema#string

Joerg Mattes

http://www.w3.org/2001/XMLSchema#string

Luke Hatchwell

http://www.w3.org/2001/XMLSchema#string

Marc E Rothenberg

http://www.w3.org/2001/XMLSchema#string

Melinda Tooze

http://www.w3.org/2001/XMLSchema#string

Nives Zimmermann

http://www.w3.org/2001/XMLSchema#string

Paul S Foster

http://www.w3.org/2001/XMLSchema#string

P2860

Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A

Asthma: clinical expression and molecular mechanisms

Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease

MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation

Interleukin-13: central mediator of allergic asthma

Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma

Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells.

Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation.

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

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232-237

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scholarly article

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10.1038/NM.3049

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2

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19

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Nathan Bartlett

Jonathan C. Morris

Nicole M Verrills

Sebastian L Johnston

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2013-01-20T00:00:00Z

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234702676

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23334847

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