Energetic landscape of alpha-lytic protease optimizes longevity through kinetic stability.
about
Unfolding simulations reveal the mechanism of extreme unfolding cooperativity in the kinetically stable alpha-lytic proteaseCrystal structure of Tk-subtilisin folded without propeptide: requirement of propeptide for acceleration of foldingFunctional modulation of a protein folding landscape via side-chain distortionThe structure of a thermostable mutant of pro-papain reveals its activation mechanismStructural and mutational analysis of a monomeric and dimeric form of a single domain antibody with implications for protein misfoldingThermodynamics of neutral protein evolutionProbing the flexibility of large conformational changes in protein structures through local perturbationsInterdomain Contacts and the Stability of Serralysin Protease from Serratia marcescensSelection for Protein Kinetic Stability Connects Denaturation Temperatures to Organismal Temperatures and Provides Clues to Archaean LifeProteolytic scanning calorimetry: a novel methodology that probes the fundamental features of protein kinetic stability.Disabling the folding catalyst is the last critical step in alpha-lytic protease foldingBotulinum neurotoxin heavy chain belt as an intramolecular chaperone for the light chainInferring stabilizing mutations from protein phylogenies: application to influenza hemagglutinin.Evolution and thermodynamics of the slow unfolding of hyperstable monomeric proteins.Highly anomalous energetics of protein cold denaturation linked to folding-unfolding kineticsSequence-dependent denaturation energetics: A major determinant in amyloid disease diversity.Evolutionary trend toward kinetic stability in the folding trajectory of RNases H.Chaperoning Anfinsen: the steric foldases.Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furinModulation of the epithelial sodium channel (ENaC) by bacterial metalloproteases and protease inhibitors.Conserved prosegment residues stabilize a late-stage folding transition state of pepsin independently of ground states.Dynamics of thermodynamically stable, kinetically trapped, and inhibitor-bound states of pepsinBacteriophage assemblyLipase-specific foldases.Candida albicans proteinases and host/pathogen interactions.Identification of critical residues in the propeptide of LasA protease of Pseudomonas aeruginosa involved in the formation of a stable mature protease.Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3.Designed protein reveals structural determinants of extreme kinetic stabilityThe folding landscape of Streptomyces griseus protease B reveals the energetic costs and benefits associated with evolving kinetic stabilityDigestion assays in allergenicity assessment of transgenic proteins.Autotransporters: The Cellular Environment Reshapes a Folding Mechanism to Promote Protein TransportSlow unfolding of monomeric proteins from hyperthermophiles with reversible unfolding.Membrane proteins can have high kinetic stability.Pro-interleukin (IL)-1beta shares a core region of stability as compared with mature IL-1beta while maintaining a distinctly different configurational landscape: a comparative hydrogen/deuterium exchange mass spectrometry study.Expanding proteome coverage with orthogonal-specificity α-lytic proteases.The role of calcium ions in the stability and instability of a thermolysin-like protease.Folding the proteome.The safety dance: biophysics of membrane protein folding and misfolding in a cellular contextPropeptides as modulators of functional activity of proteases.Energetics-based protein profiling on a proteomic scale: identification of proteins resistant to proteolysis.
P2860
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P2860
Energetic landscape of alpha-lytic protease optimizes longevity through kinetic stability.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Energetic landscape of alpha-l ...... ity through kinetic stability.
@en
Energetic landscape of alpha-l ...... ity through kinetic stability.
@nl
type
label
Energetic landscape of alpha-l ...... ity through kinetic stability.
@en
Energetic landscape of alpha-l ...... ity through kinetic stability.
@nl
prefLabel
Energetic landscape of alpha-l ...... ity through kinetic stability.
@en
Energetic landscape of alpha-l ...... ity through kinetic stability.
@nl
P2093
P356
P1433
P1476
Energetic landscape of alpha-l ...... ity through kinetic stability.
@en
P2093
David A Agard
Jonathan H Davis
Sheila S Jaswal
P2888
P304
P356
10.1038/415343A
P407
P50
P577
2002-01-01T00:00:00Z
P6179
1051626765