In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket.
about
Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity.Predicting peptides binding to MHC class II molecules using multi-objective evolutionary algorithmsPrediction of HLA-DQ8beta cell peptidome using a computational program and its relationship to autoreactive T cellsDiabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register.I-Ag7 is subject to post-translational chaperoning by CLIP.Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentationGPS-MBA: computational analysis of MHC class II epitopes in type 1 diabetesZnT8-reactive T cells are weakly pathogenic in NOD mice but can participate in diabetes under inflammatory conditionsAlloreactivity is limited by the endogenous peptide repertoireA reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes.Perspective on antigen processing and presentation.Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competitionGeneration of human alloantigen-specific T cells from peripheral blood.Cell-surface MHC density profiling reveals instability of autoimmunity-associated HLA.Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse.Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells.Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletionDo MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases?Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice.Specificity of T-cell alloreactivity.Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse.The discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylationAn endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells.The anti-insulin trimolecular complex in type 1 diabetes.MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity.The peptide-binding motif of HLA-DR8 shares important structural features with other type 1 diabetes-associated alleles.Predicting peptides bound to I-Ag7 class II histocompatibility molecules using a novel expectation-maximization alignment algorithm.Identification of naturally processed peptides bound to the class I MHC molecule H-2Kd of normal and TAP-deficient cells.Insufficient autoantigen presentation and failure of tolerance in a mouse model of rheumatoid arthritis.Alloreactive T cells respond specifically to multiple distinct peptide-MHC complexes.N-terminal flanking residues of a diabetes-associated GAD65 determinant are necessary for activation of antigen-specific T cells in diabetes-resistant mice.Chemical identification of a low abundance lysozyme peptide family bound to I-Ak histocompatibility molecules.MHC-independent genetic regulation of liver damage in a mouse model of autoimmune hepatocellular injury.The islet-resident macrophage is in an inflammatory state and senses microbial products in blood.PREDNOD, a prediction server for peptide binding to the H-2g7 haplotype of the non-obese diabetic mouse.
P2860
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P2860
In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
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2002年學術文章
@zh-hant
name
In APCs, the autologous peptid ...... acid changes in the P9 pocket.
@en
In APCs, the autologous peptid ...... acid changes in the P9 pocket.
@nl
type
label
In APCs, the autologous peptid ...... acid changes in the P9 pocket.
@en
In APCs, the autologous peptid ...... acid changes in the P9 pocket.
@nl
prefLabel
In APCs, the autologous peptid ...... acid changes in the P9 pocket.
@en
In APCs, the autologous peptid ...... acid changes in the P9 pocket.
@nl
P2093
P1476
In APCs, the autologous peptid ...... acid changes in the P9 pocket.
@en
P2093
Anish Suri
Ilan Vidavsky
Koen van der Drift
Michael L Gross
Osami Kanagawa
P304
P356
10.4049/JIMMUNOL.168.3.1235
P407
P577
2002-02-01T00:00:00Z